Targeting USP42 induces DNA damage and inhibits cell growth in prostate cancer

Targeting USP42 induces DNA damage and inhibits cell growth in prostate cancer

BackgroundProstate cancer (PCa) is one of the most common cancers in men worldwide. During its progression, deubiquitination-mediated alterations in biological processes play critical roles in tumor metabolism, stem cell characteristics, immune evasion, DNA damage repair, and chemoresistance. A comp...

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Bibliographic Details
Main Authors: Yinghao Zhou, Chenchen Chen, Yibo Meng, Jianchao Ge, Shengkui Meng, Xillong Wang, Yaozong Xu, Guowei Shi, Wandong Yu, Xuetao Hu, Jun Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Molecular Biosciences
Subjects:
prostate cancer
deubiquitinase
DNA damage response
androgen recepter
olaparib
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2025.1646331/full
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