Oral and perioral soft tissue lesions and oral functions in patients with dystrophic epidermolysis bullosa
Background/Aim. Dystrophic epidermolysis bullosa (DEB) is characterized by distinct systemic and skin changes, as well as numerous oral manifestations. The aim of the study was to examine oral and perioral soft tissues and oral functions in DEB patients by monitoring changes over a period of one yea...
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| Format: | Article |
| Language: | English |
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2022-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2022/0042-84502000128C.pdf |
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| author | Čolović Aleksandra Jovičić Olivera Mandinić Zoran Mandić Jelena Juloski Jelena |
| author_facet | Čolović Aleksandra Jovičić Olivera Mandinić Zoran Mandić Jelena Juloski Jelena |
| author_sort | Čolović Aleksandra |
| collection | DOAJ |
| description | Background/Aim. Dystrophic epidermolysis bullosa (DEB) is characterized by distinct systemic and skin changes, as well as numerous oral manifestations. The aim of the study was to examine oral and perioral soft tissues and oral functions in DEB patients by monitoring changes over a period of one year. Methods. Twenty-four patients (1 month to 36 years old) were clinically examined initially (T0), after 6 months (T6), and after 12 months (T12). Appearance and localization of perioral and oral bullae and scars, maximum mouth opening, reduced vestibule depth, absence of lingual papillae and palatal rugae, and restricted tongue movement due to scarring were monitored. The values of maximum mouth opening at the initial examination were compared to those measured in the healthy con-trol group of the same age. The age of patients and differences between the dominant and recessive subtypes of DEB were analyzed. Results. The average maximum mouth opening was significantly lower in DEB patients compared to healthy individuals. Oral and perioral bullae and scars, microstomia, and reduced vestibule depth were very common, with no statistically significant difference among T0, T6, and T12. The prevalence of restricted tongue movement due to scarring and the absence of lingual papillae and palatal rugae increased significantly over one year. Patients with microstomia, vestibule depth, and restricted tongue movement due to scarring were significantly older than patients without these characteristics. Lingual papillae and palatal rugae were more frequently absent in recessive than dominant DEB. Conclusion. DEB causes significant changes in oral and perioral soft tissues and oral functions impairment. |
| format | Article |
| id | doaj-art-a260bd9b2ea74dc2a42a29c1b170f413 |
| institution | Kabale University |
| issn | 0042-8450 2406-0720 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-a260bd9b2ea74dc2a42a29c1b170f4132025-08-20T03:38:44ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502406-07202022-01-0179435235810.2298/VSP201010128C0042-84502000128COral and perioral soft tissue lesions and oral functions in patients with dystrophic epidermolysis bullosaČolović Aleksandra0https://orcid.org/0000-0001-9057-2501Jovičić Olivera1Mandinić Zoran2https://orcid.org/0000-0003-2622-6043Mandić Jelena3https://orcid.org/0000-0002-4726-6450Juloski Jelena4https://orcid.org/0000-0002-7448-3661University of Belgrade, Faculty of Dental Medicine, Clinic for Pediatric and Preventive Dentistry, Belgrade, SerbiaUniversity of Belgrade, Faculty of Dental Medicine, Clinic for Pediatric and Preventive Dentistry, Belgrade, SerbiaUniversity of Belgrade, Faculty of Dental Medicine, Clinic for Pediatric and Preventive Dentistry, Belgrade, SerbiaUniversity of Belgrade, Faculty of Dental Medicine, Clinic for Pediatric and Preventive Dentistry, Belgrade, SerbiaUniversity of Belgrade, Faculty of Dental Medicine, Clinic for Pediatric and Preventive Dentistry, Belgrade, SerbiaBackground/Aim. Dystrophic epidermolysis bullosa (DEB) is characterized by distinct systemic and skin changes, as well as numerous oral manifestations. The aim of the study was to examine oral and perioral soft tissues and oral functions in DEB patients by monitoring changes over a period of one year. Methods. Twenty-four patients (1 month to 36 years old) were clinically examined initially (T0), after 6 months (T6), and after 12 months (T12). Appearance and localization of perioral and oral bullae and scars, maximum mouth opening, reduced vestibule depth, absence of lingual papillae and palatal rugae, and restricted tongue movement due to scarring were monitored. The values of maximum mouth opening at the initial examination were compared to those measured in the healthy con-trol group of the same age. The age of patients and differences between the dominant and recessive subtypes of DEB were analyzed. Results. The average maximum mouth opening was significantly lower in DEB patients compared to healthy individuals. Oral and perioral bullae and scars, microstomia, and reduced vestibule depth were very common, with no statistically significant difference among T0, T6, and T12. The prevalence of restricted tongue movement due to scarring and the absence of lingual papillae and palatal rugae increased significantly over one year. Patients with microstomia, vestibule depth, and restricted tongue movement due to scarring were significantly older than patients without these characteristics. Lingual papillae and palatal rugae were more frequently absent in recessive than dominant DEB. Conclusion. DEB causes significant changes in oral and perioral soft tissues and oral functions impairment.http://www.doiserbia.nb.rs/img/doi/0042-8450/2022/0042-84502000128C.pdfblistercicatrixepidermolysis bullosa dystrophicamicrostomiamouthpreventive dentistry |
| spellingShingle | Čolović Aleksandra Jovičić Olivera Mandinić Zoran Mandić Jelena Juloski Jelena Oral and perioral soft tissue lesions and oral functions in patients with dystrophic epidermolysis bullosa Vojnosanitetski Pregled blister cicatrix epidermolysis bullosa dystrophica microstomia mouth preventive dentistry |
| title | Oral and perioral soft tissue lesions and oral functions in patients with dystrophic epidermolysis bullosa |
| title_full | Oral and perioral soft tissue lesions and oral functions in patients with dystrophic epidermolysis bullosa |
| title_fullStr | Oral and perioral soft tissue lesions and oral functions in patients with dystrophic epidermolysis bullosa |
| title_full_unstemmed | Oral and perioral soft tissue lesions and oral functions in patients with dystrophic epidermolysis bullosa |
| title_short | Oral and perioral soft tissue lesions and oral functions in patients with dystrophic epidermolysis bullosa |
| title_sort | oral and perioral soft tissue lesions and oral functions in patients with dystrophic epidermolysis bullosa |
| topic | blister cicatrix epidermolysis bullosa dystrophica microstomia mouth preventive dentistry |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2022/0042-84502000128C.pdf |
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