Viral Infections as the most Frequent Causes of Undifferentiated Fever in Children Living in the Lower Mekong Region: A Systematic Review

To summarize common infections responsible for undifferentiated fever in children living in the lower Mekong region. This review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Eighteen articles were included, including eight studies that...

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Main Authors: Xuan Duong Tran, Thi Loi Dao, Nhu Ngoc Nguyen, Van Thuan Hoang, Philippe Gautret
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2024-04-01
Series:Dr. Sulaiman Al Habib Medical Journal
Subjects:
Online Access:https://journals.lww.com/10.4103/DSHMJ.DSHMJ_34_24
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author Xuan Duong Tran
Thi Loi Dao
Nhu Ngoc Nguyen
Van Thuan Hoang
Philippe Gautret
author_facet Xuan Duong Tran
Thi Loi Dao
Nhu Ngoc Nguyen
Van Thuan Hoang
Philippe Gautret
author_sort Xuan Duong Tran
collection DOAJ
description To summarize common infections responsible for undifferentiated fever in children living in the lower Mekong region. This review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Eighteen articles were included, including eight studies that were performed on both children and adults. A total of 1,017,923 patients were included in these studies, and viral infections were the most common causes of infections. Dengue virus was detected in 6%–72.8% of the patients, chikungunya virus in 15.8%–66.0% of the patients, and influenza A virus in 3.8%–18.8% of the patients. Rickettsia sp. was detected in 0%–18.9% of the patients, Leptospira was detected in 0%–27.2% of the patients, and Salmonella typhi in 2.6%–37.5% of the patients. Viral fever is the most common cause of undifferentiated fever among children in the lower Mekong region. Testing for microbial pathogens may help reduce inappropriate antibiotic use.
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institution Kabale University
issn 2666-819X
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language English
publishDate 2024-04-01
publisher Wolters Kluwer Medknow Publications
record_format Article
series Dr. Sulaiman Al Habib Medical Journal
spelling doaj-art-a25a1dd1069242d38881ae60ce744fcd2025-08-21T04:58:07ZengWolters Kluwer Medknow PublicationsDr. Sulaiman Al Habib Medical Journal2666-819X2590-33492024-04-0162354510.4103/DSHMJ.DSHMJ_34_24Viral Infections as the most Frequent Causes of Undifferentiated Fever in Children Living in the Lower Mekong Region: A Systematic ReviewXuan Duong TranThi Loi DaoNhu Ngoc NguyenVan Thuan HoangPhilippe GautretTo summarize common infections responsible for undifferentiated fever in children living in the lower Mekong region. This review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Eighteen articles were included, including eight studies that were performed on both children and adults. A total of 1,017,923 patients were included in these studies, and viral infections were the most common causes of infections. Dengue virus was detected in 6%–72.8% of the patients, chikungunya virus in 15.8%–66.0% of the patients, and influenza A virus in 3.8%–18.8% of the patients. Rickettsia sp. was detected in 0%–18.9% of the patients, Leptospira was detected in 0%–27.2% of the patients, and Salmonella typhi in 2.6%–37.5% of the patients. Viral fever is the most common cause of undifferentiated fever among children in the lower Mekong region. Testing for microbial pathogens may help reduce inappropriate antibiotic use.https://journals.lww.com/10.4103/DSHMJ.DSHMJ_34_24childrenfever of unknown originfever without sourceundifferentiated fever
spellingShingle Xuan Duong Tran
Thi Loi Dao
Nhu Ngoc Nguyen
Van Thuan Hoang
Philippe Gautret
Viral Infections as the most Frequent Causes of Undifferentiated Fever in Children Living in the Lower Mekong Region: A Systematic Review
Dr. Sulaiman Al Habib Medical Journal
children
fever of unknown origin
fever without source
undifferentiated fever
title Viral Infections as the most Frequent Causes of Undifferentiated Fever in Children Living in the Lower Mekong Region: A Systematic Review
title_full Viral Infections as the most Frequent Causes of Undifferentiated Fever in Children Living in the Lower Mekong Region: A Systematic Review
title_fullStr Viral Infections as the most Frequent Causes of Undifferentiated Fever in Children Living in the Lower Mekong Region: A Systematic Review
title_full_unstemmed Viral Infections as the most Frequent Causes of Undifferentiated Fever in Children Living in the Lower Mekong Region: A Systematic Review
title_short Viral Infections as the most Frequent Causes of Undifferentiated Fever in Children Living in the Lower Mekong Region: A Systematic Review
title_sort viral infections as the most frequent causes of undifferentiated fever in children living in the lower mekong region a systematic review
topic children
fever of unknown origin
fever without source
undifferentiated fever
url https://journals.lww.com/10.4103/DSHMJ.DSHMJ_34_24
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AT vanthuanhoang viralinfectionsasthemostfrequentcausesofundifferentiatedfeverinchildrenlivinginthelowermekongregionasystematicreview
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