PRC1 as an independent adverse prognostic factor in Wilms tumor via integrated bioinformatics and experimental validation

PRC1 as an independent adverse prognostic factor in Wilms tumor via integrated bioinformatics and experimental validation

Abstract Wilms Tumor (WT), a prevalent pediatric renal malignancy, exhibits marked heterogeneity and variable clinical outcomes. Epithelial-mesenchymal transition (EMT), a biological process enabling epithelial cells to acquire mesenchymal traits associated with enhanced migratory and invasive capac...

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Bibliographic Details
Main Authors: Yanping Wang, Hongjie Gao, Xuetian Li, Ding Li, Fan Huang, Yuqiang Sun, Xingjian Liu, Junli Yang, Fengyin Sun
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Wilms tumor
PRC1
Prognostic
EMT
Bulk RNA-Seq
Single-cell RNA-seq
Online Access:https://doi.org/10.1038/s41598-025-98030-y
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