Some Deafness-Causing Mutations Can Be Silenced with the Appropriate Gene Partner
Inheritance of a deafness-causing genotype does not necessarily mean that a person will have profound hearing loss. The presence of a modifying gene can change the effect of the deafness genotype. As an example, mutations found commonly among the deaf are at times found among their normal hearing re...
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| Format: | Article |
| Language: | English |
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Wiley
2001-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2001.40 |
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| _version_ | 1849398106694615040 |
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| author | Edward Wilcox Saima Riazuddin Sheikh Riazuddin |
| author_facet | Edward Wilcox Saima Riazuddin Sheikh Riazuddin |
| author_sort | Edward Wilcox |
| collection | DOAJ |
| description | Inheritance of a deafness-causing genotype does not necessarily mean that a person will have profound hearing loss. The presence of a modifying gene can change the effect of the deafness genotype. As an example, mutations found commonly among the deaf are at times found among their normal hearing relatives [1]. The implication is that there are genes or gene products whose interactions allow the normal physiological function of the inner ear despite a mutation that would normally disrupt the process. Deafness is not the first disorder in which modifiers can change the expected outcome, nor will it be the last, but it is very unusual for the outcome to be so dramatically changed. |
| format | Article |
| id | doaj-art-a2564a1c1cf1499497d2beddd8a727de |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2001-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-a2564a1c1cf1499497d2beddd8a727de2025-08-20T03:38:43ZengWileyThe Scientific World Journal1537-744X2001-01-01120220310.1100/tsw.2001.40Some Deafness-Causing Mutations Can Be Silenced with the Appropriate Gene PartnerEdward Wilcox0Saima Riazuddin1Sheikh Riazuddin2Laboratory of Molecular Genetics, NIDCD, NIH, Rockville, MD 20850-3227, USALaboratory of Molecular Genetics, NIDCD, NIH, Rockville, MD 20850-3227, USALaboratory of Molecular Genetics, NIDCD, NIH, Rockville, MD 20850-3227, USAInheritance of a deafness-causing genotype does not necessarily mean that a person will have profound hearing loss. The presence of a modifying gene can change the effect of the deafness genotype. As an example, mutations found commonly among the deaf are at times found among their normal hearing relatives [1]. The implication is that there are genes or gene products whose interactions allow the normal physiological function of the inner ear despite a mutation that would normally disrupt the process. Deafness is not the first disorder in which modifiers can change the expected outcome, nor will it be the last, but it is very unusual for the outcome to be so dramatically changed.http://dx.doi.org/10.1100/tsw.2001.40 |
| spellingShingle | Edward Wilcox Saima Riazuddin Sheikh Riazuddin Some Deafness-Causing Mutations Can Be Silenced with the Appropriate Gene Partner The Scientific World Journal |
| title | Some Deafness-Causing Mutations Can Be Silenced with the Appropriate Gene Partner |
| title_full | Some Deafness-Causing Mutations Can Be Silenced with the Appropriate Gene Partner |
| title_fullStr | Some Deafness-Causing Mutations Can Be Silenced with the Appropriate Gene Partner |
| title_full_unstemmed | Some Deafness-Causing Mutations Can Be Silenced with the Appropriate Gene Partner |
| title_short | Some Deafness-Causing Mutations Can Be Silenced with the Appropriate Gene Partner |
| title_sort | some deafness causing mutations can be silenced with the appropriate gene partner |
| url | http://dx.doi.org/10.1100/tsw.2001.40 |
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