Neutrophils in cancer: At the crucial crossroads of anti‐tumor and pro‐tumor
Abstract Neutrophils are important components of the immune system and play a key role in defending against pathogenic infections and responding to inflammatory cues, including cancer. Their dysregulation indicates potential disease risk factors. However, their functional importance in disease progr...
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| Format: | Article |
| Language: | English |
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Wiley
2025-08-01
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| Series: | Cancer Communications |
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| Online Access: | https://doi.org/10.1002/cac2.70027 |
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| _version_ | 1849233341987946496 |
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| author | Wenpeng Cai Tao Fan Chu Xiao Ziqin Deng Yixiao Liu Chunxiang Li Jie He |
| author_facet | Wenpeng Cai Tao Fan Chu Xiao Ziqin Deng Yixiao Liu Chunxiang Li Jie He |
| author_sort | Wenpeng Cai |
| collection | DOAJ |
| description | Abstract Neutrophils are important components of the immune system and play a key role in defending against pathogenic infections and responding to inflammatory cues, including cancer. Their dysregulation indicates potential disease risk factors. However, their functional importance in disease progression has often been underestimated due to their short half‐life, especially as there is limited information on the role of intratumoral neutrophils. Recent studies on their prominent role in cancer have led to a paradigm shift in our understanding of the functional diversity of neutrophils. These studies highlight that neutrophils have emerged as key components of the tumor microenvironment, where they can play a dual role in promoting and suppressing cancer. Moreover, several approaches to therapeutically target neutrophils have emerged, and clinical trials are investigating their efficacy. In this review, we discussed the involvement of neutrophils in cancer initiation and progression. We summarized recent advances in therapeutic strategies targeting neutrophils and, most importantly, suggested future research directions that could facilitate the manipulation of neutrophils for therapeutic purposes in cancer patients. |
| format | Article |
| id | doaj-art-a253832f3b4e4ba6921c4f1bcaf2e6c9 |
| institution | Kabale University |
| issn | 2523-3548 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Communications |
| spelling | doaj-art-a253832f3b4e4ba6921c4f1bcaf2e6c92025-08-20T08:40:33ZengWileyCancer Communications2523-35482025-08-0145888891310.1002/cac2.70027Neutrophils in cancer: At the crucial crossroads of anti‐tumor and pro‐tumorWenpeng Cai0Tao Fan1Chu Xiao2Ziqin Deng3Yixiao Liu4Chunxiang Li5Jie He6Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing P. R. ChinaDepartment of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing P. R. ChinaDepartment of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing P. R. ChinaDepartment of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing P. R. ChinaDepartment of Colorectal Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing P. R. ChinaDepartment of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing P. R. ChinaDepartment of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing P. R. ChinaAbstract Neutrophils are important components of the immune system and play a key role in defending against pathogenic infections and responding to inflammatory cues, including cancer. Their dysregulation indicates potential disease risk factors. However, their functional importance in disease progression has often been underestimated due to their short half‐life, especially as there is limited information on the role of intratumoral neutrophils. Recent studies on their prominent role in cancer have led to a paradigm shift in our understanding of the functional diversity of neutrophils. These studies highlight that neutrophils have emerged as key components of the tumor microenvironment, where they can play a dual role in promoting and suppressing cancer. Moreover, several approaches to therapeutically target neutrophils have emerged, and clinical trials are investigating their efficacy. In this review, we discussed the involvement of neutrophils in cancer initiation and progression. We summarized recent advances in therapeutic strategies targeting neutrophils and, most importantly, suggested future research directions that could facilitate the manipulation of neutrophils for therapeutic purposes in cancer patients.https://doi.org/10.1002/cac2.70027tumor‐associated neutrophiltumor microenvironmentcancer therapyimmunology |
| spellingShingle | Wenpeng Cai Tao Fan Chu Xiao Ziqin Deng Yixiao Liu Chunxiang Li Jie He Neutrophils in cancer: At the crucial crossroads of anti‐tumor and pro‐tumor Cancer Communications tumor‐associated neutrophil tumor microenvironment cancer therapy immunology |
| title | Neutrophils in cancer: At the crucial crossroads of anti‐tumor and pro‐tumor |
| title_full | Neutrophils in cancer: At the crucial crossroads of anti‐tumor and pro‐tumor |
| title_fullStr | Neutrophils in cancer: At the crucial crossroads of anti‐tumor and pro‐tumor |
| title_full_unstemmed | Neutrophils in cancer: At the crucial crossroads of anti‐tumor and pro‐tumor |
| title_short | Neutrophils in cancer: At the crucial crossroads of anti‐tumor and pro‐tumor |
| title_sort | neutrophils in cancer at the crucial crossroads of anti tumor and pro tumor |
| topic | tumor‐associated neutrophil tumor microenvironment cancer therapy immunology |
| url | https://doi.org/10.1002/cac2.70027 |
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