Establishing reference values for amplitude-integrated electroencephalography in preterms below 35 weeks of gestational age: A prospective observational cohort study
Characteristic patterns in amplitude-integrated electroencephalography (aEEG) develop with gestational age (GA), and so can be used to evaluate brain maturation in premature infants. Reference aEEG values in normal preterm infants have not been identified and data are scarce. We aimed to vali...
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Hacettepe University Institute of Child Health
2016-12-01
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| Series: | The Turkish Journal of Pediatrics |
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| Online Access: | https://turkjpediatr.org/article/view/1167 |
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| author | Young Mi Han Na Rae Lee Mi Hye Bae Kyung Hee Park Yun Jin Lee Sang Ook Nam Shin Yun Byun |
| author_facet | Young Mi Han Na Rae Lee Mi Hye Bae Kyung Hee Park Yun Jin Lee Sang Ook Nam Shin Yun Byun |
| author_sort | Young Mi Han |
| collection | DOAJ |
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Characteristic patterns in amplitude-integrated electroencephalography (aEEG) develop with gestational age (GA), and so can be used to evaluate brain maturation in premature infants. Reference aEEG values in normal preterm infants have not been identified and data are scarce. We aimed to validate a currently available aEEG scoring system. We also investigated the development of aEEG activity during the first week after birth, determining reference values in preterm infants with no abnormal cranial ultrasound findings. We prospectively studied aEEG and cranial ultrasounds in infants with a GA of < 35 weeks. We conducted aEEG at 12-14 hours, 46-48 hours, 70-72 hours, and 1 week after birth. The aEEG recordings were evaluated using Burdjalov criteria, scored by two independent neonatologists. Thirty-four infants were enrolled and completed the 1-week evaluation. GA ranged from 24 to 35 weeks and birth weights varied between 570 and 2,100 g. We analyzed 134 aEEG tracings, with a mean difference between raters of -0.05. Total scores, summed from scores for each assessed variable, increased gradually with advancing gestational and postnatal age. However, highest scores were not attained until 35 weeks' gestational age. There was high inter-rater agreement for aEEG scoring, and we could ascertain some approximate reference values for aEEG development in preterm infants at varying GA. To establish standardized aEEG reference criteria, further studies in larger cohorts of premature infants should be performed over longer periods.
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| format | Article |
| id | doaj-art-a2412d890987475a9f5d41b2639dfa5a |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2016-12-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-a2412d890987475a9f5d41b2639dfa5a2025-08-20T03:01:11ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212016-12-0158610.24953/turkjped.2016.06.004Establishing reference values for amplitude-integrated electroencephalography in preterms below 35 weeks of gestational age: A prospective observational cohort studyYoung Mi Han0Na Rae Lee1Mi Hye Bae2Kyung Hee Park3Yun Jin Lee4Sang Ook Nam5Shin Yun Byun6Division of Neonatology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.Division of Neonatology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.Division of Neonatology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.Division of Neonatology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.Division of Neurology, Department of Pediatrics, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.Division of Neurology, Department of Pediatrics, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.Division of Neonatology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea. Characteristic patterns in amplitude-integrated electroencephalography (aEEG) develop with gestational age (GA), and so can be used to evaluate brain maturation in premature infants. Reference aEEG values in normal preterm infants have not been identified and data are scarce. We aimed to validate a currently available aEEG scoring system. We also investigated the development of aEEG activity during the first week after birth, determining reference values in preterm infants with no abnormal cranial ultrasound findings. We prospectively studied aEEG and cranial ultrasounds in infants with a GA of < 35 weeks. We conducted aEEG at 12-14 hours, 46-48 hours, 70-72 hours, and 1 week after birth. The aEEG recordings were evaluated using Burdjalov criteria, scored by two independent neonatologists. Thirty-four infants were enrolled and completed the 1-week evaluation. GA ranged from 24 to 35 weeks and birth weights varied between 570 and 2,100 g. We analyzed 134 aEEG tracings, with a mean difference between raters of -0.05. Total scores, summed from scores for each assessed variable, increased gradually with advancing gestational and postnatal age. However, highest scores were not attained until 35 weeks' gestational age. There was high inter-rater agreement for aEEG scoring, and we could ascertain some approximate reference values for aEEG development in preterm infants at varying GA. To establish standardized aEEG reference criteria, further studies in larger cohorts of premature infants should be performed over longer periods. https://turkjpediatr.org/article/view/1167amplitude-integrated electroencephalographycerebral function monitorpreterm infantreference values |
| spellingShingle | Young Mi Han Na Rae Lee Mi Hye Bae Kyung Hee Park Yun Jin Lee Sang Ook Nam Shin Yun Byun Establishing reference values for amplitude-integrated electroencephalography in preterms below 35 weeks of gestational age: A prospective observational cohort study The Turkish Journal of Pediatrics amplitude-integrated electroencephalography cerebral function monitor preterm infant reference values |
| title | Establishing reference values for amplitude-integrated electroencephalography in preterms below 35 weeks of gestational age: A prospective observational cohort study |
| title_full | Establishing reference values for amplitude-integrated electroencephalography in preterms below 35 weeks of gestational age: A prospective observational cohort study |
| title_fullStr | Establishing reference values for amplitude-integrated electroencephalography in preterms below 35 weeks of gestational age: A prospective observational cohort study |
| title_full_unstemmed | Establishing reference values for amplitude-integrated electroencephalography in preterms below 35 weeks of gestational age: A prospective observational cohort study |
| title_short | Establishing reference values for amplitude-integrated electroencephalography in preterms below 35 weeks of gestational age: A prospective observational cohort study |
| title_sort | establishing reference values for amplitude integrated electroencephalography in preterms below 35 weeks of gestational age a prospective observational cohort study |
| topic | amplitude-integrated electroencephalography cerebral function monitor preterm infant reference values |
| url | https://turkjpediatr.org/article/view/1167 |
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