Unleashing the potential of a low CpG Passer transposon for superior CAR-T cell therapy

Unleashing the potential of a low CpG Passer transposon for superior CAR-T cell therapy

BackgroundTo date, the non-viral vector Chimeric Antigen Receptor (CAR) T cell preparation platform, exemplified by transposons, has demonstrated significant potential in tumor immunotherapy and yielded positive results in multiple clinical trials. Nonetheless, non-methylated CpG sequences within pl...

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Bibliographic Details
Main Authors: Jianyao Zeng, Yan Sun, Yuan Fang, Xiaodie Wang, Qian Huang, Pingjing Zhang, Meiqi Shao, Pei Wang, Jingbo Cheng, Meng Di, Tao Liu, Qijun Qian
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
methylation
CpG motif
chimeric antigen receptor T cell
transposon
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1541653/full
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