Direct Arp2/3-vinculin binding is required for pseudopod extension, but only on compliant substrates and in 3D

Direct Arp2/3-vinculin binding is required for pseudopod extension, but only on compliant substrates and in 3D

Summary: A critical step in cell morphogenesis is the extension of actin-dense pseudopods, controlled by actin-binding proteins (ABPs). While this process is well-understood on glass coverslips, it is less so in compliant three-dimensional environments. Here, we knocked out a series of ABPs in osteo...

Full description

Saved in:
Bibliographic Details
Main Authors: Tadamoto Isogai, Kevin M. Dean, Philippe Roudot, Evgenia V. Azarova, Kushal Bhatt, Meghan K. Driscoll, Shaina P. Royer, Nikhil Mittal, Bo-Jui Chang, Sangyoon J. Han, Reto Fiolka, Gaudenz Danuser
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:iScience
Subjects:
Biological morphology
Molecular biology
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225008843
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items