Antihypertensive effect of allicin in dexamethasone-induced hypertensive rats
Background: Glucocorticoid is among the most commonly prescribed medicine. Unfortunately, Excess glucocorticoid level leads hypertension in 80–90% patients. Garlic (Allium sativum) has been used since ancient times and even nowadays as a part of popular medicine for various ailments and physiologica...
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| Language: | English |
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Elsevier
2017-03-01
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| Series: | Integrative Medicine Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213422016300877 |
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| author | Harikesh Dubey Anamika Singh Angad M. Patole Chandrashekhar R. Tenpe |
| author_facet | Harikesh Dubey Anamika Singh Angad M. Patole Chandrashekhar R. Tenpe |
| author_sort | Harikesh Dubey |
| collection | DOAJ |
| description | Background: Glucocorticoid is among the most commonly prescribed medicine. Unfortunately, Excess glucocorticoid level leads hypertension in 80–90% patients. Garlic (Allium sativum) has been used since ancient times and even nowadays as a part of popular medicine for various ailments and physiological disorders. Hence this study was undertaken to investigate the antihypertensive activity of allicin in dexamethasone induced hypertension in wistar rats.
Methods: The animals were randomly divided into four groups comprising of six rats per group. Hypertension was induced by subcutaneous injection of dexamethasone (10 μg/rat/day) in hypertensive rats. Two hypertensive group animals were treated with nicorandil (6 mg/kg/day, po) and allicin (8 mg/kg/day, po) respectively for 8 weeks. While systolic blood pressure (SBP) was measured by the tail-cuff method weekly up to 8 weeks.
Results: Dexamethasone treatment resulted in significant increase in SBP while allicin treatment significantly decreases the SBP. Thus, this study confirmed that allicin treatment for 8 weeks partially reverse dexamethasone induced hypertension in rats. Allicin treatment also attenuated dexamethasone-induced anorexia and loss of total body weight.
Conclusion: This result suggests antihypertensive effects of allicin in dexamethasone induced hypertension. However, further studies are needed to explore the detailed mechanism of antihypertensive effect of allicin. |
| format | Article |
| id | doaj-art-a22f554d206a4b54a2c8e8cf667bf746 |
| institution | Kabale University |
| issn | 2213-4220 |
| language | English |
| publishDate | 2017-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Integrative Medicine Research |
| spelling | doaj-art-a22f554d206a4b54a2c8e8cf667bf7462025-08-20T03:38:38ZengElsevierIntegrative Medicine Research2213-42202017-03-0161606510.1016/j.imr.2016.12.002Antihypertensive effect of allicin in dexamethasone-induced hypertensive ratsHarikesh Dubey0Anamika Singh1Angad M. Patole2Chandrashekhar R. Tenpe3Department of Pharmacology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, IndiaDepartment of Pharmacology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, IndiaDepartment of Pharmacology, Institute of Pharmaceutical Education and Research, Wardha, IndiaDepartment of Pharmacology, Institute of Pharmaceutical Education and Research, Wardha, IndiaBackground: Glucocorticoid is among the most commonly prescribed medicine. Unfortunately, Excess glucocorticoid level leads hypertension in 80–90% patients. Garlic (Allium sativum) has been used since ancient times and even nowadays as a part of popular medicine for various ailments and physiological disorders. Hence this study was undertaken to investigate the antihypertensive activity of allicin in dexamethasone induced hypertension in wistar rats. Methods: The animals were randomly divided into four groups comprising of six rats per group. Hypertension was induced by subcutaneous injection of dexamethasone (10 μg/rat/day) in hypertensive rats. Two hypertensive group animals were treated with nicorandil (6 mg/kg/day, po) and allicin (8 mg/kg/day, po) respectively for 8 weeks. While systolic blood pressure (SBP) was measured by the tail-cuff method weekly up to 8 weeks. Results: Dexamethasone treatment resulted in significant increase in SBP while allicin treatment significantly decreases the SBP. Thus, this study confirmed that allicin treatment for 8 weeks partially reverse dexamethasone induced hypertension in rats. Allicin treatment also attenuated dexamethasone-induced anorexia and loss of total body weight. Conclusion: This result suggests antihypertensive effects of allicin in dexamethasone induced hypertension. However, further studies are needed to explore the detailed mechanism of antihypertensive effect of allicin.http://www.sciencedirect.com/science/article/pii/S2213422016300877AllicinGlucocorticoidDexamethasoneHypertensionNicorandil |
| spellingShingle | Harikesh Dubey Anamika Singh Angad M. Patole Chandrashekhar R. Tenpe Antihypertensive effect of allicin in dexamethasone-induced hypertensive rats Integrative Medicine Research Allicin Glucocorticoid Dexamethasone Hypertension Nicorandil |
| title | Antihypertensive effect of allicin in dexamethasone-induced hypertensive rats |
| title_full | Antihypertensive effect of allicin in dexamethasone-induced hypertensive rats |
| title_fullStr | Antihypertensive effect of allicin in dexamethasone-induced hypertensive rats |
| title_full_unstemmed | Antihypertensive effect of allicin in dexamethasone-induced hypertensive rats |
| title_short | Antihypertensive effect of allicin in dexamethasone-induced hypertensive rats |
| title_sort | antihypertensive effect of allicin in dexamethasone induced hypertensive rats |
| topic | Allicin Glucocorticoid Dexamethasone Hypertension Nicorandil |
| url | http://www.sciencedirect.com/science/article/pii/S2213422016300877 |
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