Efficient Generation of Megakaryocyte Progenitors and Platelets From HSPCs via JAK2/STAT3 Signaling

Efficient Generation of Megakaryocyte Progenitors and Platelets From HSPCs via JAK2/STAT3 Signaling

Abstract The supply of platelets for clinical transfusion is often insufficient to meet growing demand. Platelet regeneration from stem cells offers a potential solution to reduce reliance on donor‐based transfusions. However, the current differentiation efficiency is suboptimal. A novel approach is...

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Bibliographic Details
Main Authors: Huicong Liu, Lingna Wang, Jiaqing Liu, Haitao Yuan, Kaiqing Zhang, Yun Qiu, Fangfang Zhu
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Advanced Science
Subjects:
GABA
HDAC
HES7
JAK/STAT
megakaryocyte progenitor
platelet
Online Access:https://doi.org/10.1002/advs.202500612
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