Secernin‐2 Stabilizes Histone Methyltransferase KMT2C to Suppress Progression and Confer Therapeutic Sensitivity to PARP Inhibition in Triple‐Negative Breast Cancer

Secernin‐2 Stabilizes Histone Methyltransferase KMT2C to Suppress Progression and Confer Therapeutic Sensitivity to PARP Inhibition in Triple‐Negative Breast Cancer

Abstract Triple‐negative breast cancer (TNBC) is a difficulty and bottleneck in the clinical treatment of breast cancer due to a lack of effective therapeutic targets. Herein, we first report that secernin 2 (SCRN2), an uncharacterized gene in human cancer, acts as a novel tumor suppressor in TNBC t...

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Bibliographic Details
Main Authors: Min‐Ying Huang, Jia‐Yang Cai, Shao‐Ying Yang, Qian Zhao, Zhi‐Min Shao, Fang‐Lin Zhang, Yin‐Ling Zhang, A‐Yong Cao, Da‐Qiang Li
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
DNA damage response
lysine methyltransferase
PARP inhibition
triple‐negative breast cancer
tumor suppressor
Online Access:https://doi.org/10.1002/advs.202413280
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