Predictors of response to bDMARDs and tsDMARDs in psoriatic arthritis: a pilot study on the role of musculoskeletal ultrasound
ObjectivesThis pilot study aimed to identify early predictors of drug retention in patients with clinically active peripheral psoriatic arthritis who initiated or switched to therapy with biologic and targeted synthetic disease-modifying antirheumatic drugs (bDMARDs and tsDMARDs).MethodsClinical and...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1482894/full |
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| author | Giacomo Cozzi Laura Scagnellato Mariagrazia Lorenzin Antonio Collesei Francesca Oliviero Amelia Damasco Chiara Cosma Daniela Basso Andrea Doria Roberta Ramonda |
| author_facet | Giacomo Cozzi Laura Scagnellato Mariagrazia Lorenzin Antonio Collesei Francesca Oliviero Amelia Damasco Chiara Cosma Daniela Basso Andrea Doria Roberta Ramonda |
| author_sort | Giacomo Cozzi |
| collection | DOAJ |
| description | ObjectivesThis pilot study aimed to identify early predictors of drug retention in patients with clinically active peripheral psoriatic arthritis who initiated or switched to therapy with biologic and targeted synthetic disease-modifying antirheumatic drugs (bDMARDs and tsDMARDs).MethodsClinical and ultrasound assessments were conducted at baseline (t0) and subsequently at 1 (t1), 3 (t3), and 6 (t6) months. Ultrasound evaluations targeted joints/entheses according to PsASon-Score13 and the most clinically involved joint/enthesis/tendon or the two most clinically involved joints/entheses/tendons (MIJET and 2MIJET). After 6 months of follow-up, patients were divided into two groups based on drug retention, determined by the clinician's assessment of treatment efficacy (cResponder vs. non-cResponder). Main endpoints were ultrasound changes in MIJET, 2MIJET, and GUIS (Global US Inflammation Subscore) derived from PsASon-13.ResultsTwenty-nine patients were enrolled, 22 cResponders and 7 non-cResponders at t6. In the comparison between cResponders and non-cResponders, GUIS variation significantly differed in Δt6-t0, while MIJET and 2MIJET variations were significant as early as Δt3-t0 and confirmed in Δt6-t0. The ultrasound response of MIJET and 2MIJET was faster in cResponders treated with JAKi vs. those treated with TNFi and IL-17/12-23i, significant in Δt1-t0.ConclusionsUltrasound imaging of clinically involved joint sites may be a valuable early predictor of therapy response for predicting drug retention at 6 months in patients with psoriatic arthritis. |
| format | Article |
| id | doaj-art-a22ab9402ae5403e80dc00b08a29c873 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-a22ab9402ae5403e80dc00b08a29c8732024-12-23T06:39:09ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2024-12-011110.3389/fmed.2024.14828941482894Predictors of response to bDMARDs and tsDMARDs in psoriatic arthritis: a pilot study on the role of musculoskeletal ultrasoundGiacomo Cozzi0Laura Scagnellato1Mariagrazia Lorenzin2Antonio Collesei3Francesca Oliviero4Amelia Damasco5Chiara Cosma6Daniela Basso7Andrea Doria8Roberta Ramonda9Rheumatology Unit, Department of Medicine-DIMED, University - Padova University Hospital, Padua, ItalyRheumatology Unit, Department of Medicine-DIMED, University - Padova University Hospital, Padua, ItalyRheumatology Unit, Department of Medicine-DIMED, University - Padova University Hospital, Padua, ItalyCancer Genomics Core-Lab, Istituto Oncologico Veneto IRCCS, Padua, ItalyRheumatology Unit, Department of Medicine-DIMED, University - Padova University Hospital, Padua, ItalyRheumatology Unit, Department of Medicine-DIMED, University - Padova University Hospital, Padua, ItalyLaboratory Medicine, Department of Medicine-DIMED, University - Padova University Hospital, Padua, ItalyLaboratory Medicine, Department of Medicine-DIMED, University - Padova University Hospital, Padua, ItalyRheumatology Unit, Department of Medicine-DIMED, University - Padova University Hospital, Padua, ItalyRheumatology Unit, Department of Medicine-DIMED, University - Padova University Hospital, Padua, ItalyObjectivesThis pilot study aimed to identify early predictors of drug retention in patients with clinically active peripheral psoriatic arthritis who initiated or switched to therapy with biologic and targeted synthetic disease-modifying antirheumatic drugs (bDMARDs and tsDMARDs).MethodsClinical and ultrasound assessments were conducted at baseline (t0) and subsequently at 1 (t1), 3 (t3), and 6 (t6) months. Ultrasound evaluations targeted joints/entheses according to PsASon-Score13 and the most clinically involved joint/enthesis/tendon or the two most clinically involved joints/entheses/tendons (MIJET and 2MIJET). After 6 months of follow-up, patients were divided into two groups based on drug retention, determined by the clinician's assessment of treatment efficacy (cResponder vs. non-cResponder). Main endpoints were ultrasound changes in MIJET, 2MIJET, and GUIS (Global US Inflammation Subscore) derived from PsASon-13.ResultsTwenty-nine patients were enrolled, 22 cResponders and 7 non-cResponders at t6. In the comparison between cResponders and non-cResponders, GUIS variation significantly differed in Δt6-t0, while MIJET and 2MIJET variations were significant as early as Δt3-t0 and confirmed in Δt6-t0. The ultrasound response of MIJET and 2MIJET was faster in cResponders treated with JAKi vs. those treated with TNFi and IL-17/12-23i, significant in Δt1-t0.ConclusionsUltrasound imaging of clinically involved joint sites may be a valuable early predictor of therapy response for predicting drug retention at 6 months in patients with psoriatic arthritis.https://www.frontiersin.org/articles/10.3389/fmed.2024.1482894/fullpsoriatic arthritisbDMARDstsDMARDsultrasoundtherapy response |
| spellingShingle | Giacomo Cozzi Laura Scagnellato Mariagrazia Lorenzin Antonio Collesei Francesca Oliviero Amelia Damasco Chiara Cosma Daniela Basso Andrea Doria Roberta Ramonda Predictors of response to bDMARDs and tsDMARDs in psoriatic arthritis: a pilot study on the role of musculoskeletal ultrasound Frontiers in Medicine psoriatic arthritis bDMARDs tsDMARDs ultrasound therapy response |
| title | Predictors of response to bDMARDs and tsDMARDs in psoriatic arthritis: a pilot study on the role of musculoskeletal ultrasound |
| title_full | Predictors of response to bDMARDs and tsDMARDs in psoriatic arthritis: a pilot study on the role of musculoskeletal ultrasound |
| title_fullStr | Predictors of response to bDMARDs and tsDMARDs in psoriatic arthritis: a pilot study on the role of musculoskeletal ultrasound |
| title_full_unstemmed | Predictors of response to bDMARDs and tsDMARDs in psoriatic arthritis: a pilot study on the role of musculoskeletal ultrasound |
| title_short | Predictors of response to bDMARDs and tsDMARDs in psoriatic arthritis: a pilot study on the role of musculoskeletal ultrasound |
| title_sort | predictors of response to bdmards and tsdmards in psoriatic arthritis a pilot study on the role of musculoskeletal ultrasound |
| topic | psoriatic arthritis bDMARDs tsDMARDs ultrasound therapy response |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1482894/full |
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