Mechanobiological mechanism of cyclic stretch-induced cell columnarization

Summary: In vivo, epithelial cells maintain structural integrity under dynamic mechanical perturbations. To study this, we treated various epithelial cell lines with long-term cyclic stretch (CS). Surprisingly, cells transitioned from cuboidal to columnar shape (columnarization) in MDCK cells, while...

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Bibliographic Details
Main Authors: Lun-Wei Lee, Gang-Hui Lee, I-Hsiu Su, Chia-Hsuan Lu, Keng-Hui Lin, Fu-Lai Wen, Ming-Jer Tang
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Cell Reports
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Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725004334
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