High throughput morphological screening identifies chemically defined media for mesenchymal stromal cells that enhances proliferation and supports maintenance of immunomodulatory function

High throughput morphological screening identifies chemically defined media for mesenchymal stromal cells that enhances proliferation and supports maintenance of immunomodulatory function

Abstract Background While mesenchymal stromal cell (MSC) therapies show promise for treating several indications due to their regenerative and immunomodulatory capacity, clinical translation has yet to be achieved due to a lack of robust, scalable manufacturing practices. Expansion using undefined f...

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Bibliographic Details
Main Authors: Thomas M. Spoerer, Andrew M. Larey, Winifred Asigri, Kanupriya R. Daga, Ross A. Marklein
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stromal cells
Defined medium
Immunomodulation
High throughput screening
Morphology
Cell therapy
Online Access:https://doi.org/10.1186/s13287-025-04206-8
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