Renal Dysfunction in Patients with Left Ventricular Assist Device
Late-stage heart failure and renal dysfunction are often seen in conjunction. Cardiorenal syndrome (CRS) describes the complex interaction between the two disease states. Early literature described the pathophysiology of CRS as related only to reduced cardiac output and decreased renal perfusion. Re...
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| Language: | English |
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Houston Methodist DeBakey Heart & Vascular Center
2022-09-01
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| Series: | Methodist DeBakey Cardiovascular Journal |
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| Online Access: | https://account.journal.houstonmethodist.org/index.php/up-j-mdbcj/article/view/1146 |
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| author | Lamees I. El Nihum Nina Manian Priya Arunachalam Qasim Al Abri Ashrith Guha |
| author_facet | Lamees I. El Nihum Nina Manian Priya Arunachalam Qasim Al Abri Ashrith Guha |
| author_sort | Lamees I. El Nihum |
| collection | DOAJ |
| description | Late-stage heart failure and renal dysfunction are often seen in conjunction. Cardiorenal syndrome (CRS) describes the complex interaction between the two disease states. Early literature described the pathophysiology of CRS as related only to reduced cardiac output and decreased renal perfusion. Recent literature suggests a more multifaceted mechanism. Left ventricular assist devices (LVAD), used as bridge-to-transplant and destination therapy in patients with heart failure, impact not only cardiac function but also renal function, especially in those patients with preoperative renal dysfunction. The mechanism by which LVAD implantation affects renal function is complex and understated in early literature. In this review, we discuss the pathogenesis of CRS, the impact of preoperative renal dysfunction in patients undergoing LVAD implantation, and the effect of LVAD implantation on postoperative renal function. |
| format | Article |
| id | doaj-art-a21f8b6ee10a4392ae29c0b6e1bbebb7 |
| institution | OA Journals |
| issn | 1947-6108 |
| language | English |
| publishDate | 2022-09-01 |
| publisher | Houston Methodist DeBakey Heart & Vascular Center |
| record_format | Article |
| series | Methodist DeBakey Cardiovascular Journal |
| spelling | doaj-art-a21f8b6ee10a4392ae29c0b6e1bbebb72025-08-20T02:33:23ZengHouston Methodist DeBakey Heart & Vascular CenterMethodist DeBakey Cardiovascular Journal1947-61082022-09-01184192610.14797/mdcvj.1146479Renal Dysfunction in Patients with Left Ventricular Assist DeviceLamees I. El Nihum0Nina Manian1Priya Arunachalam2https://orcid.org/0000-0002-0026-5127Qasim Al Abri3Ashrith Guha4https://orcid.org/0000-0002-7246-9508Methodist DeBakey Heart & Vascular CenterMethodist DeBakey Heart & Vascular Center, Houston Methodist, Houston, Texas; Texas A&M College of Medicine, Bryan, TexasMethodist DeBakey Heart & Vascular Center, Houston Methodist, Houston, Texas; Texas A&M College of Medicine, Bryan, TexasMethodist DeBakey Heart & Vascular Center, Houston Methodist, Houston, TexasMethodist DeBakey Heart & Vascular Center, Houston Methodist, Houston, TexasLate-stage heart failure and renal dysfunction are often seen in conjunction. Cardiorenal syndrome (CRS) describes the complex interaction between the two disease states. Early literature described the pathophysiology of CRS as related only to reduced cardiac output and decreased renal perfusion. Recent literature suggests a more multifaceted mechanism. Left ventricular assist devices (LVAD), used as bridge-to-transplant and destination therapy in patients with heart failure, impact not only cardiac function but also renal function, especially in those patients with preoperative renal dysfunction. The mechanism by which LVAD implantation affects renal function is complex and understated in early literature. In this review, we discuss the pathogenesis of CRS, the impact of preoperative renal dysfunction in patients undergoing LVAD implantation, and the effect of LVAD implantation on postoperative renal function.https://account.journal.houstonmethodist.org/index.php/up-j-mdbcj/article/view/1146lvadleft ventricular assist devicerenal dysfunction |
| spellingShingle | Lamees I. El Nihum Nina Manian Priya Arunachalam Qasim Al Abri Ashrith Guha Renal Dysfunction in Patients with Left Ventricular Assist Device Methodist DeBakey Cardiovascular Journal lvad left ventricular assist device renal dysfunction |
| title | Renal Dysfunction in Patients with Left Ventricular Assist Device |
| title_full | Renal Dysfunction in Patients with Left Ventricular Assist Device |
| title_fullStr | Renal Dysfunction in Patients with Left Ventricular Assist Device |
| title_full_unstemmed | Renal Dysfunction in Patients with Left Ventricular Assist Device |
| title_short | Renal Dysfunction in Patients with Left Ventricular Assist Device |
| title_sort | renal dysfunction in patients with left ventricular assist device |
| topic | lvad left ventricular assist device renal dysfunction |
| url | https://account.journal.houstonmethodist.org/index.php/up-j-mdbcj/article/view/1146 |
| work_keys_str_mv | AT lameesielnihum renaldysfunctioninpatientswithleftventricularassistdevice AT ninamanian renaldysfunctioninpatientswithleftventricularassistdevice AT priyaarunachalam renaldysfunctioninpatientswithleftventricularassistdevice AT qasimalabri renaldysfunctioninpatientswithleftventricularassistdevice AT ashrithguha renaldysfunctioninpatientswithleftventricularassistdevice |