Influence of migrasome-associated long noncoding RNAs on the immune microenvironment and prognosis in lung adenocarcinoma
Abstract This study investigated the prognostic impact of migrasome-related long noncoding RNAs (lncRNAs) in lung adenocarcinoma (LUAD). We analyzed transcriptomic data from The Cancer Genome Atlas (TCGA) database, comprising 541 tumor samples and 59 normal tissue samples, to pinpoint key migrasome...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer
2025-06-01
|
| Series: | Discover Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s12672-025-03000-5 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849238394138263552 |
|---|---|
| author | Hui Zhao Kunpeng Yang Yuejiao Lan Mingda Wu Lei Wang Chenglun Cai Peiyun Lv Wenjuan Sun Xiaodan Lu Bao Wang |
| author_facet | Hui Zhao Kunpeng Yang Yuejiao Lan Mingda Wu Lei Wang Chenglun Cai Peiyun Lv Wenjuan Sun Xiaodan Lu Bao Wang |
| author_sort | Hui Zhao |
| collection | DOAJ |
| description | Abstract This study investigated the prognostic impact of migrasome-related long noncoding RNAs (lncRNAs) in lung adenocarcinoma (LUAD). We analyzed transcriptomic data from The Cancer Genome Atlas (TCGA) database, comprising 541 tumor samples and 59 normal tissue samples, to pinpoint key migrasome genes and related lncRNAs, using correlation analysis to detect those pertinent to patient outcomes. A risk score model based on 17 migrasome-related lncRNAs, constructed via univariate, LASSO, and multivariate Cox regression, was then validated in an independent dataset to ensure reliability. Our findings revealed that high-risk patients exhibited worse overall and progression-free survival, alongside altered immune features, such as potential immune evasion and an increased propensity for immunotherapy responsiveness. Moreover, Tumor Immune Dysfunction and Exclusion (TIDE) analyses suggested that individuals with higher scores could experience greater benefit from immune checkpoint inhibitors. Functional enrichment analysis supported the engagement of migrasome-related pathways and immune-regulatory processes that may drive disease progression. Additionally, principal component analysis (PCA) confirmed the robustness of our lncRNA-driven classifier, enabling accurate differentiation of risk cohorts. Overall, our study underscores the contribution of migrasome-related lncRNAs in predicting LUAD prognosis and informing clinical choices, shedding light on tumor biology and immunotherapy response. These results emphasize the clinical importance of migrasome-related lncRNAs as promising therapeutic targets and prognostic biomarkers in LUAD management. |
| format | Article |
| id | doaj-art-a21d907c824248a3b17dad99d00f09a5 |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-a21d907c824248a3b17dad99d00f09a52025-08-20T04:01:36ZengSpringerDiscover Oncology2730-60112025-06-0116112010.1007/s12672-025-03000-5Influence of migrasome-associated long noncoding RNAs on the immune microenvironment and prognosis in lung adenocarcinomaHui Zhao0Kunpeng Yang1Yuejiao Lan2Mingda Wu3Lei Wang4Chenglun Cai5Peiyun Lv6Wenjuan Sun7Xiaodan Lu8Bao Wang9Jilin Cancer HospitalJilin Cancer HospitalPrecision Medicine Center, Jilin People’s HospitalPrecision Medicine Center, Jilin People’s HospitalJilin Cancer HospitalJilin Cancer HospitalJilin Cancer HospitalChangchun University of Chinese MedicinePrecision Medicine Center, Jilin People’s HospitalJilin Cancer HospitalAbstract This study investigated the prognostic impact of migrasome-related long noncoding RNAs (lncRNAs) in lung adenocarcinoma (LUAD). We analyzed transcriptomic data from The Cancer Genome Atlas (TCGA) database, comprising 541 tumor samples and 59 normal tissue samples, to pinpoint key migrasome genes and related lncRNAs, using correlation analysis to detect those pertinent to patient outcomes. A risk score model based on 17 migrasome-related lncRNAs, constructed via univariate, LASSO, and multivariate Cox regression, was then validated in an independent dataset to ensure reliability. Our findings revealed that high-risk patients exhibited worse overall and progression-free survival, alongside altered immune features, such as potential immune evasion and an increased propensity for immunotherapy responsiveness. Moreover, Tumor Immune Dysfunction and Exclusion (TIDE) analyses suggested that individuals with higher scores could experience greater benefit from immune checkpoint inhibitors. Functional enrichment analysis supported the engagement of migrasome-related pathways and immune-regulatory processes that may drive disease progression. Additionally, principal component analysis (PCA) confirmed the robustness of our lncRNA-driven classifier, enabling accurate differentiation of risk cohorts. Overall, our study underscores the contribution of migrasome-related lncRNAs in predicting LUAD prognosis and informing clinical choices, shedding light on tumor biology and immunotherapy response. These results emphasize the clinical importance of migrasome-related lncRNAs as promising therapeutic targets and prognostic biomarkers in LUAD management.https://doi.org/10.1007/s12672-025-03000-5LncRNAsLUADMigrasomesPrognosisImmunotherapy |
| spellingShingle | Hui Zhao Kunpeng Yang Yuejiao Lan Mingda Wu Lei Wang Chenglun Cai Peiyun Lv Wenjuan Sun Xiaodan Lu Bao Wang Influence of migrasome-associated long noncoding RNAs on the immune microenvironment and prognosis in lung adenocarcinoma Discover Oncology LncRNAs LUAD Migrasomes Prognosis Immunotherapy |
| title | Influence of migrasome-associated long noncoding RNAs on the immune microenvironment and prognosis in lung adenocarcinoma |
| title_full | Influence of migrasome-associated long noncoding RNAs on the immune microenvironment and prognosis in lung adenocarcinoma |
| title_fullStr | Influence of migrasome-associated long noncoding RNAs on the immune microenvironment and prognosis in lung adenocarcinoma |
| title_full_unstemmed | Influence of migrasome-associated long noncoding RNAs on the immune microenvironment and prognosis in lung adenocarcinoma |
| title_short | Influence of migrasome-associated long noncoding RNAs on the immune microenvironment and prognosis in lung adenocarcinoma |
| title_sort | influence of migrasome associated long noncoding rnas on the immune microenvironment and prognosis in lung adenocarcinoma |
| topic | LncRNAs LUAD Migrasomes Prognosis Immunotherapy |
| url | https://doi.org/10.1007/s12672-025-03000-5 |
| work_keys_str_mv | AT huizhao influenceofmigrasomeassociatedlongnoncodingrnasontheimmunemicroenvironmentandprognosisinlungadenocarcinoma AT kunpengyang influenceofmigrasomeassociatedlongnoncodingrnasontheimmunemicroenvironmentandprognosisinlungadenocarcinoma AT yuejiaolan influenceofmigrasomeassociatedlongnoncodingrnasontheimmunemicroenvironmentandprognosisinlungadenocarcinoma AT mingdawu influenceofmigrasomeassociatedlongnoncodingrnasontheimmunemicroenvironmentandprognosisinlungadenocarcinoma AT leiwang influenceofmigrasomeassociatedlongnoncodingrnasontheimmunemicroenvironmentandprognosisinlungadenocarcinoma AT chengluncai influenceofmigrasomeassociatedlongnoncodingrnasontheimmunemicroenvironmentandprognosisinlungadenocarcinoma AT peiyunlv influenceofmigrasomeassociatedlongnoncodingrnasontheimmunemicroenvironmentandprognosisinlungadenocarcinoma AT wenjuansun influenceofmigrasomeassociatedlongnoncodingrnasontheimmunemicroenvironmentandprognosisinlungadenocarcinoma AT xiaodanlu influenceofmigrasomeassociatedlongnoncodingrnasontheimmunemicroenvironmentandprognosisinlungadenocarcinoma AT baowang influenceofmigrasomeassociatedlongnoncodingrnasontheimmunemicroenvironmentandprognosisinlungadenocarcinoma |