Potential C-terminal domain interactions of the cardiac voltage gated sodium channel

Potential C-terminal domain interactions of the cardiac voltage gated sodium channel

Abstract CryoEM structural characterization of the cardiac sodium channel (NaV1.5) captured the cytosolic C-terminal domain (CTD) interacting with the cytosolic loop that connects domains III and IV (inactivation gate). Our previous modeling efforts focused on improving descriptions of the cytosolic...

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Bibliographic Details
Main Authors: Spencer K. Lile, Emily M. Campbell, Rita F. Gyawu, Jarrod A. Smith, Steven R. Gwaltney, Christopher N. Johnson
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Voltage-gated sodium channels
C-terminal domain interaction
IQ motif
Inactivation gate
Activation gate
Latch-receptor interaction
Online Access:https://doi.org/10.1038/s41598-025-98912-1
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