Regulation of actin cytoskeletal dynamics in T cell development and function
T cell development and function depend on precise remodeling of the actin cytoskeleton, which regulates migration, cell division, immunological synapse formation, and signal transduction. Regulators of actin include nucleators (Arp2/3, Formins) and binding proteins (coronins, cofilin, myosin) that o...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1622928/full |
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| author | Trang T. Lam Trang T. Lam Mark M. W. Chong Mark M. W. Chong |
| author_facet | Trang T. Lam Trang T. Lam Mark M. W. Chong Mark M. W. Chong |
| author_sort | Trang T. Lam |
| collection | DOAJ |
| description | T cell development and function depend on precise remodeling of the actin cytoskeleton, which regulates migration, cell division, immunological synapse formation, and signal transduction. Regulators of actin include nucleators (Arp2/3, Formins) and binding proteins (coronins, cofilin, myosin) that orchestrate cytoskeletal dynamics to ensure efficient antigen recognition and signaling, while Rho GTPases (Rac1, Cdc42, RhoA) link extracellular cues to actin rearrangements, influencing both conventional T cell activation and function. Dysregulated actin dynamics contribute to immunodeficiencies and autoimmunity, and thus understanding how the actin cytoskeleton is regulated in T cells has important implications. |
| format | Article |
| id | doaj-art-a2191c77c73b408aa2e20fbe051935b0 |
| institution | DOAJ |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-a2191c77c73b408aa2e20fbe051935b02025-08-20T03:10:20ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-06-011610.3389/fimmu.2025.16229281622928Regulation of actin cytoskeletal dynamics in T cell development and functionTrang T. Lam0Trang T. Lam1Mark M. W. Chong2Mark M. W. Chong3St Vincent’s Institute of Medical Research, Fitzroy, VIC, AustraliaDepartment of Medicine (St Vincent’s), University of Melbourne, Fitzroy, VIC, AustraliaSt Vincent’s Institute of Medical Research, Fitzroy, VIC, AustraliaDepartment of Medicine (St Vincent’s), University of Melbourne, Fitzroy, VIC, AustraliaT cell development and function depend on precise remodeling of the actin cytoskeleton, which regulates migration, cell division, immunological synapse formation, and signal transduction. Regulators of actin include nucleators (Arp2/3, Formins) and binding proteins (coronins, cofilin, myosin) that orchestrate cytoskeletal dynamics to ensure efficient antigen recognition and signaling, while Rho GTPases (Rac1, Cdc42, RhoA) link extracellular cues to actin rearrangements, influencing both conventional T cell activation and function. Dysregulated actin dynamics contribute to immunodeficiencies and autoimmunity, and thus understanding how the actin cytoskeleton is regulated in T cells has important implications.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1622928/fullT cellsT cell developmentcoroninactin cytoskeletal dynamicsactin-binding proteinsimmunological synapse |
| spellingShingle | Trang T. Lam Trang T. Lam Mark M. W. Chong Mark M. W. Chong Regulation of actin cytoskeletal dynamics in T cell development and function Frontiers in Immunology T cells T cell development coronin actin cytoskeletal dynamics actin-binding proteins immunological synapse |
| title | Regulation of actin cytoskeletal dynamics in T cell development and function |
| title_full | Regulation of actin cytoskeletal dynamics in T cell development and function |
| title_fullStr | Regulation of actin cytoskeletal dynamics in T cell development and function |
| title_full_unstemmed | Regulation of actin cytoskeletal dynamics in T cell development and function |
| title_short | Regulation of actin cytoskeletal dynamics in T cell development and function |
| title_sort | regulation of actin cytoskeletal dynamics in t cell development and function |
| topic | T cells T cell development coronin actin cytoskeletal dynamics actin-binding proteins immunological synapse |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1622928/full |
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