Mesenchymal Stem Cell-derived Exosomes: Novel Therapeutic Approach for Inflammatory Bowel Diseases
As double membrane-encapsulated nanovesicles (30-150 nm), exosomes (Exos) shuttle between different cells to mediate intercellular communication and transport active cargoes of paracrine factors. The anti-inflammatory and immunomodulatory activities of mesenchymal stem cell (MSC)-derived Exos (MSC-E...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2023/4245704 |
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| _version_ | 1832547937529364480 |
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| author | Cheng-mei Tian Mei-feng Yang Hao-ming Xu Min-zheng Zhu Yuan Zhang Jun Yao Li-sheng Wang Yu-jie Liang De-feng Li |
| author_facet | Cheng-mei Tian Mei-feng Yang Hao-ming Xu Min-zheng Zhu Yuan Zhang Jun Yao Li-sheng Wang Yu-jie Liang De-feng Li |
| author_sort | Cheng-mei Tian |
| collection | DOAJ |
| description | As double membrane-encapsulated nanovesicles (30-150 nm), exosomes (Exos) shuttle between different cells to mediate intercellular communication and transport active cargoes of paracrine factors. The anti-inflammatory and immunomodulatory activities of mesenchymal stem cell (MSC)-derived Exos (MSC-Exos) provide a rationale for novel cell-free therapies for inflammatory bowel disease (IBD). Growing evidence has shown that MSC-Exos can be a potential candidate for treating IBD. In the present review, we summarized the most critical advances in the properties of MSC-Exos, provided the research progress of MSC-Exos in treating IBD, and discussed the molecular mechanisms underlying these effects. Collectively, MSC-Exos had great potential for cell-free therapy in IBD. However, further studies are required to understand the full dimensions of the complex Exo system and how to optimize its effects. |
| format | Article |
| id | doaj-art-a217aa7371ea4f4ab3a9946d55aa3b21 |
| institution | Kabale University |
| issn | 1687-9678 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-a217aa7371ea4f4ab3a9946d55aa3b212025-02-03T06:42:52ZengWileyStem Cells International1687-96782023-01-01202310.1155/2023/4245704Mesenchymal Stem Cell-derived Exosomes: Novel Therapeutic Approach for Inflammatory Bowel DiseasesCheng-mei Tian0Mei-feng Yang1Hao-ming Xu2Min-zheng Zhu3Yuan Zhang4Jun Yao5Li-sheng Wang6Yu-jie Liang7De-feng Li8Department of GastroenterologyDepartment of HematologyDepartment of Gastroenterology and HepatologyDepartment of Gastroenterology and HepatologyDepartment of Medical AdministrationDepartment of GastroenterologyDepartment of GastroenterologyDepartment of Child and Adolescent PsychiatryDepartment of GastroenterologyAs double membrane-encapsulated nanovesicles (30-150 nm), exosomes (Exos) shuttle between different cells to mediate intercellular communication and transport active cargoes of paracrine factors. The anti-inflammatory and immunomodulatory activities of mesenchymal stem cell (MSC)-derived Exos (MSC-Exos) provide a rationale for novel cell-free therapies for inflammatory bowel disease (IBD). Growing evidence has shown that MSC-Exos can be a potential candidate for treating IBD. In the present review, we summarized the most critical advances in the properties of MSC-Exos, provided the research progress of MSC-Exos in treating IBD, and discussed the molecular mechanisms underlying these effects. Collectively, MSC-Exos had great potential for cell-free therapy in IBD. However, further studies are required to understand the full dimensions of the complex Exo system and how to optimize its effects.http://dx.doi.org/10.1155/2023/4245704 |
| spellingShingle | Cheng-mei Tian Mei-feng Yang Hao-ming Xu Min-zheng Zhu Yuan Zhang Jun Yao Li-sheng Wang Yu-jie Liang De-feng Li Mesenchymal Stem Cell-derived Exosomes: Novel Therapeutic Approach for Inflammatory Bowel Diseases Stem Cells International |
| title | Mesenchymal Stem Cell-derived Exosomes: Novel Therapeutic Approach for Inflammatory Bowel Diseases |
| title_full | Mesenchymal Stem Cell-derived Exosomes: Novel Therapeutic Approach for Inflammatory Bowel Diseases |
| title_fullStr | Mesenchymal Stem Cell-derived Exosomes: Novel Therapeutic Approach for Inflammatory Bowel Diseases |
| title_full_unstemmed | Mesenchymal Stem Cell-derived Exosomes: Novel Therapeutic Approach for Inflammatory Bowel Diseases |
| title_short | Mesenchymal Stem Cell-derived Exosomes: Novel Therapeutic Approach for Inflammatory Bowel Diseases |
| title_sort | mesenchymal stem cell derived exosomes novel therapeutic approach for inflammatory bowel diseases |
| url | http://dx.doi.org/10.1155/2023/4245704 |
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