Inflammation and autophagy in peripheral nerves of rodent models with metabolic syndrome and type 2 diabetes mellitus
Metabolic syndrome (MetS) and type 2 diabetes mellitus (T2D) are associated with inflammation and the accumulation of macrophages in peripheral nerves, which increases the risk of developing peripheral neuropathy (PN). We have previously investigated that macrophage infiltration in the peripheral ne...
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| Language: | English |
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Elsevier
2025-07-01
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| Series: | Neuroscience Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0168010225000707 |
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| author | Petra Baum Thomas Ebert Nora Klöting Sontje Krupka Matthias König Sabine Paeschke Peggy Stock Michal Bulc Matthias Blüher Katarzyna Palus Marcin Nowicki Joanna Kosacka |
| author_facet | Petra Baum Thomas Ebert Nora Klöting Sontje Krupka Matthias König Sabine Paeschke Peggy Stock Michal Bulc Matthias Blüher Katarzyna Palus Marcin Nowicki Joanna Kosacka |
| author_sort | Petra Baum |
| collection | DOAJ |
| description | Metabolic syndrome (MetS) and type 2 diabetes mellitus (T2D) are associated with inflammation and the accumulation of macrophages in peripheral nerves, which increases the risk of developing peripheral neuropathy (PN). We have previously investigated that macrophage infiltration in the peripheral nerves of animals with T2D (leptin-deficient ob/ob mice, leptin receptor-deficient db/db) correlated with PN, whereas this process in animals with MetS (Wistar Ottawa Karlsburg W (RT1u) WOKW rat) did not lead to neuropathic changes. Additional data presented in this study suggest an association between increased mRNA expression of the anti-inflammatory marker IL-10 and autophagy in the prevention of neuropathy. |
| format | Article |
| id | doaj-art-a213f820552a4e808cacf153346e7ddc |
| institution | OA Journals |
| issn | 0168-0102 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neuroscience Research |
| spelling | doaj-art-a213f820552a4e808cacf153346e7ddc2025-08-20T02:08:38ZengElsevierNeuroscience Research0168-01022025-07-0121610489910.1016/j.neures.2025.04.002Inflammation and autophagy in peripheral nerves of rodent models with metabolic syndrome and type 2 diabetes mellitusPetra Baum0Thomas Ebert1Nora Klöting2Sontje Krupka3Matthias König4Sabine Paeschke5Peggy Stock6Michal Bulc7Matthias Blüher8Katarzyna Palus9Marcin Nowicki10Joanna Kosacka11Department of Neurology, University of Leipzig, Liebigstr. 20, Leipzig 04103, GermanyUniversity of Leipzig Medical Center, Medical Department III – Endocrinology, Nephrology, Rheumatology, Liebigstr. 20, Leipzig 04103, GermanyHelmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig, Ph.-Rosenthal-Str. 27, Leipzig 04103, GermanyHelmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig, Ph.-Rosenthal-Str. 27, Leipzig 04103, GermanyInstitute for Biology, Institute for Theoretical Biology, Humboldt-University Berlin, Philippstraße 13, Berlin 10115, GermanyInstitute of Anatomy, University of Leipzig, Liebigstr. 13, Leipzig 04103, GermanyDepartment of General, Visceral and Vascular Surgery, Jena University Hospital, Jena 07747, GermanyDepartment of Clinical Physiology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Street Oczapowskiego 14, Olsztyn 10-719, PolandUniversity of Leipzig Medical Center, Medical Department III – Endocrinology, Nephrology, Rheumatology, Liebigstr. 20, Leipzig 04103, Germany; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig, Ph.-Rosenthal-Str. 27, Leipzig 04103, GermanyDepartment of Clinical Physiology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Street Oczapowskiego 14, Olsztyn 10-719, PolandInstitute of Anatomy, University of Leipzig, Liebigstr. 13, Leipzig 04103, GermanyDepartment of Neurology, University of Leipzig, Liebigstr. 20, Leipzig 04103, Germany; Department of General, Visceral and Vascular Surgery, Jena University Hospital, Jena 07747, Germany; Corresponding author at: Department of Neurology, University of Leipzig, Liebigstr. 20, Leipzig 04103, Germany.Metabolic syndrome (MetS) and type 2 diabetes mellitus (T2D) are associated with inflammation and the accumulation of macrophages in peripheral nerves, which increases the risk of developing peripheral neuropathy (PN). We have previously investigated that macrophage infiltration in the peripheral nerves of animals with T2D (leptin-deficient ob/ob mice, leptin receptor-deficient db/db) correlated with PN, whereas this process in animals with MetS (Wistar Ottawa Karlsburg W (RT1u) WOKW rat) did not lead to neuropathic changes. Additional data presented in this study suggest an association between increased mRNA expression of the anti-inflammatory marker IL-10 and autophagy in the prevention of neuropathy.http://www.sciencedirect.com/science/article/pii/S0168010225000707InflammationAutophagyMetabolic syndromeT2DPDNob/ob mice |
| spellingShingle | Petra Baum Thomas Ebert Nora Klöting Sontje Krupka Matthias König Sabine Paeschke Peggy Stock Michal Bulc Matthias Blüher Katarzyna Palus Marcin Nowicki Joanna Kosacka Inflammation and autophagy in peripheral nerves of rodent models with metabolic syndrome and type 2 diabetes mellitus Neuroscience Research Inflammation Autophagy Metabolic syndrome T2D PDN ob/ob mice |
| title | Inflammation and autophagy in peripheral nerves of rodent models with metabolic syndrome and type 2 diabetes mellitus |
| title_full | Inflammation and autophagy in peripheral nerves of rodent models with metabolic syndrome and type 2 diabetes mellitus |
| title_fullStr | Inflammation and autophagy in peripheral nerves of rodent models with metabolic syndrome and type 2 diabetes mellitus |
| title_full_unstemmed | Inflammation and autophagy in peripheral nerves of rodent models with metabolic syndrome and type 2 diabetes mellitus |
| title_short | Inflammation and autophagy in peripheral nerves of rodent models with metabolic syndrome and type 2 diabetes mellitus |
| title_sort | inflammation and autophagy in peripheral nerves of rodent models with metabolic syndrome and type 2 diabetes mellitus |
| topic | Inflammation Autophagy Metabolic syndrome T2D PDN ob/ob mice |
| url | http://www.sciencedirect.com/science/article/pii/S0168010225000707 |
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