Feasibility of home-based transcranial direct current stimulation combined with personalized word retrieval for improving naming in primary progressive aphasia
Background/ObjectivesPrimary progressive aphasia (PPA) is managed with speech-language therapy (SLT) to slow language decline. Pairing transcranial direct current stimulation (tDCS) with SLT can enhance its effects. However, further research is needed to confirm these findings and guide its clinical...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1543712/full |
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| author | Allan George Eric McConathey Amy Vogel-Eyny Elizabeth Galletta Giuseppina Pilloni Leigh Charvet |
| author_facet | Allan George Eric McConathey Amy Vogel-Eyny Elizabeth Galletta Giuseppina Pilloni Leigh Charvet |
| author_sort | Allan George |
| collection | DOAJ |
| description | Background/ObjectivesPrimary progressive aphasia (PPA) is managed with speech-language therapy (SLT) to slow language decline. Pairing transcranial direct current stimulation (tDCS) with SLT can enhance its effects. However, further research is needed to confirm these findings and guide its clinical use. We evaluated the feasibility of providing an intervention combining tDCS with SLT as a home-based and remotely supervised intervention.MethodsParticipants with confirmed PPA who had word-finding difficulties were recruited for an open-label observational study. The intervention consisted of 20 daily sessions over 1 month, each with 45-min of personalized word retrieval training. During the first 30-min, participants received tDCS over the left inferior frontal gyrus (anode F7, cathode O1) at 2.0 mA. Language measures were remotely administered at baseline and intervention end.ResultsWe enrolled 10 patients (age: 70 ± 7 years; 60% male) with confirmed logopenic variant (n = 2), semantic variant (n = 2), or unspecified (n = 6) PPA. The intervention was well-tolerated with no treatment-limiting adverse events. All participants completed all sessions, confirming the feasibility of the home-based treatment. There were no declines in language functioning measures, with improved naming for trained vs. untrained items (p = 0.003) and a significant improvement in confrontation naming (p = 0.016) from baseline to intervention end.ConclusionsOur case series demonstrates that home-based tDCS added to SLT is feasible for patients with PPA. However, larger controlled studies are required to confirm its effectiveness in slowing language decline and to fully determine the benefits of this approach. This approach not only facilitates broader access to participation but also enables the extended treatment necessary to evaluate its clinical benefits, moving this treatment closer to clinical availability as a telehealth treatment. |
| format | Article |
| id | doaj-art-a2105af052824a22a0dca46554d68da9 |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-a2105af052824a22a0dca46554d68da92025-02-11T15:04:20ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-02-011610.3389/fneur.2025.15437121543712Feasibility of home-based transcranial direct current stimulation combined with personalized word retrieval for improving naming in primary progressive aphasiaAllan George0Eric McConathey1Amy Vogel-Eyny2Elizabeth Galletta3Giuseppina Pilloni4Leigh Charvet5Department of Neurology, New York University Grossman School of Medicine, New York, NY, United StatesDepartment of Neurology, New York University Grossman School of Medicine, New York, NY, United StatesRusk Rehabilitation, New York University Langone Health, New York, NY, United StatesRusk Rehabilitation, New York University Langone Health, New York, NY, United StatesDepartment of Neurology, New York University Grossman School of Medicine, New York, NY, United StatesDepartment of Neurology, New York University Grossman School of Medicine, New York, NY, United StatesBackground/ObjectivesPrimary progressive aphasia (PPA) is managed with speech-language therapy (SLT) to slow language decline. Pairing transcranial direct current stimulation (tDCS) with SLT can enhance its effects. However, further research is needed to confirm these findings and guide its clinical use. We evaluated the feasibility of providing an intervention combining tDCS with SLT as a home-based and remotely supervised intervention.MethodsParticipants with confirmed PPA who had word-finding difficulties were recruited for an open-label observational study. The intervention consisted of 20 daily sessions over 1 month, each with 45-min of personalized word retrieval training. During the first 30-min, participants received tDCS over the left inferior frontal gyrus (anode F7, cathode O1) at 2.0 mA. Language measures were remotely administered at baseline and intervention end.ResultsWe enrolled 10 patients (age: 70 ± 7 years; 60% male) with confirmed logopenic variant (n = 2), semantic variant (n = 2), or unspecified (n = 6) PPA. The intervention was well-tolerated with no treatment-limiting adverse events. All participants completed all sessions, confirming the feasibility of the home-based treatment. There were no declines in language functioning measures, with improved naming for trained vs. untrained items (p = 0.003) and a significant improvement in confrontation naming (p = 0.016) from baseline to intervention end.ConclusionsOur case series demonstrates that home-based tDCS added to SLT is feasible for patients with PPA. However, larger controlled studies are required to confirm its effectiveness in slowing language decline and to fully determine the benefits of this approach. This approach not only facilitates broader access to participation but also enables the extended treatment necessary to evaluate its clinical benefits, moving this treatment closer to clinical availability as a telehealth treatment.https://www.frontiersin.org/articles/10.3389/fneur.2025.1543712/fullaphasiatDCStelemedicinehome-based tDCSSLTprimary progressive aphasia |
| spellingShingle | Allan George Eric McConathey Amy Vogel-Eyny Elizabeth Galletta Giuseppina Pilloni Leigh Charvet Feasibility of home-based transcranial direct current stimulation combined with personalized word retrieval for improving naming in primary progressive aphasia Frontiers in Neurology aphasia tDCS telemedicine home-based tDCS SLT primary progressive aphasia |
| title | Feasibility of home-based transcranial direct current stimulation combined with personalized word retrieval for improving naming in primary progressive aphasia |
| title_full | Feasibility of home-based transcranial direct current stimulation combined with personalized word retrieval for improving naming in primary progressive aphasia |
| title_fullStr | Feasibility of home-based transcranial direct current stimulation combined with personalized word retrieval for improving naming in primary progressive aphasia |
| title_full_unstemmed | Feasibility of home-based transcranial direct current stimulation combined with personalized word retrieval for improving naming in primary progressive aphasia |
| title_short | Feasibility of home-based transcranial direct current stimulation combined with personalized word retrieval for improving naming in primary progressive aphasia |
| title_sort | feasibility of home based transcranial direct current stimulation combined with personalized word retrieval for improving naming in primary progressive aphasia |
| topic | aphasia tDCS telemedicine home-based tDCS SLT primary progressive aphasia |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1543712/full |
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