The potential impact of glycine supplementation on the process of aging
Aging is a multifactorial process characterized by the progressive loss of cellular integrity, metabolic flexibility, mitochondrial function, and the gradual accumulation of oxidative and inflammatory damage. These changes increase vulnerability to age-related disorders, including cardiovascular di...
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| Format: | Article |
| Language: | English |
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Nicolaus Copernicus University in Toruń
2025-02-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/57686 |
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| author | Michalina Wójcikiewicz Julia Kulbacka Witold Czyż Julia Kacperczyk Karol Dziedzic Marta Chuncia-Ileczko Maciej Wojszczyk Damian Zys Piotr Pasek Julia Ryniecka Wiktor Czaja Michał Krzciuk |
| author_facet | Michalina Wójcikiewicz Julia Kulbacka Witold Czyż Julia Kacperczyk Karol Dziedzic Marta Chuncia-Ileczko Maciej Wojszczyk Damian Zys Piotr Pasek Julia Ryniecka Wiktor Czaja Michał Krzciuk |
| author_sort | Michalina Wójcikiewicz |
| collection | DOAJ |
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Aging is a multifactorial process characterized by the progressive loss of cellular integrity, metabolic flexibility, mitochondrial function, and the gradual accumulation of oxidative and inflammatory damage. These changes increase vulnerability to age-related disorders, including cardiovascular disease, neurodegenerative conditions, metabolic syndrome, and frailty. Glycine, the simplest amino acid, has recently gained attention as a potential nutritional and therapeutic intervention to modulate various pathways implicated in aging. Beyond its structural role in collagen and other proteins, glycine is a critical precursor for glutathione- an essential intracellular antioxidant- plays a role in neurotransmission, and is involved in the synthesis of heme, creatine, and bile acids. Emerging studies suggest that glycine supplementation may alleviate oxidative stress, dampen chronic low-grade inflammation, improve insulin sensitivity, enhance mitochondrial function, and even mimic aspects of methionine restriction- a dietary approach known to extend lifespan in animal models. These combined effects may help preserve physiological function, slow the onset of age-associated diseases, and promote healthspan. Nevertheless, the evidence base is still evolving; most current data derive from animal models, in vitro experiments, and limited human trials. Rigorous, long-term, randomized controlled studies are needed to identify optimal dosing, determine long-term safety, and clarify whether glycine can be strategically leveraged as an anti-aging nutrient. If confirmed, glycine’s safety, affordability, and accessibility may make it a compelling option for improving the quality of aging worldwide.
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| format | Article |
| id | doaj-art-a20b11f0e7904d619b6091b0d890edf9 |
| institution | Kabale University |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-a20b11f0e7904d619b6091b0d890edf92025-02-03T08:23:59ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-02-013810.12775/QS.2025.38.57686The potential impact of glycine supplementation on the process of agingMichalina Wójcikiewicz0https://orcid.org/0009-0003-3671-1410Julia Kulbacka1https://orcid.org/0009-0005-1181-9104Witold Czyż2https://orcid.org/0009-0006-4442-9900Julia Kacperczyk3https://orcid.org/0009-0007-6354-301XKarol Dziedzic4https://orcid.org/0009-0007-8317-723XMarta Chuncia-Ileczko5https://orcid.org/0009-0000-0913-9752Maciej Wojszczyk6https://orcid.org/0009-0002-8668-8821Damian Zys7https://orcid.org/0009-0003-6578-6710Piotr Pasek8https://orcid.org/0009-0001-6218-9887Julia Ryniecka9https://orcid.org/0009-0000-5937-9498Wiktor Czaja10https://orcid.org/0009-0004-6221-2954Michał Krzciuk11https://orcid.org/0009-0004-2230-3456Central Teaching Hospital of the Medical University of Lodz, Pomorska 251, 92-213 Lodz, PolandCentral Teaching Hospital of the Medical University of Lodz, Pomorska 251, 92-213 Lodz, PolandCentral Teaching Hospital of the Medical University of Lodz, Pomorska 251, 92-213 Lodz, PolandMedical University of Łódź al. T. Kościuszki 4, 90–419 Łódź, Polska Medical University of Lodz, Al T .Kosciuszki 4, 90-419 Lodz, PolandCentral Teaching Hospital of the Medical University of LodzUniversity Clinical Hospital No. 1 of the Medical University of Lodz, ul. Kopcińskiego 22, 90-153 ŁódźUniversity Clinical Hospital No. 1 of the Medical University of Lodz, ul. Kopcińskiego 22, 90-153 Lodz, PolandCopernicus Memorial Hospital, ul. Pabianicka 62, 93-513 Lodz, PolandMedical University of Lodz, Al T .Kosciuszki 4, 90-419 Lodz, PolandPomeranian Medical University in Szczecin Rybacka Street 1, 70-204 Szczecin, Poland Pomeranian Medical University in Szczecin Rybacka Street 1, 70-204 Szczecin, Poland Aging is a multifactorial process characterized by the progressive loss of cellular integrity, metabolic flexibility, mitochondrial function, and the gradual accumulation of oxidative and inflammatory damage. These changes increase vulnerability to age-related disorders, including cardiovascular disease, neurodegenerative conditions, metabolic syndrome, and frailty. Glycine, the simplest amino acid, has recently gained attention as a potential nutritional and therapeutic intervention to modulate various pathways implicated in aging. Beyond its structural role in collagen and other proteins, glycine is a critical precursor for glutathione- an essential intracellular antioxidant- plays a role in neurotransmission, and is involved in the synthesis of heme, creatine, and bile acids. Emerging studies suggest that glycine supplementation may alleviate oxidative stress, dampen chronic low-grade inflammation, improve insulin sensitivity, enhance mitochondrial function, and even mimic aspects of methionine restriction- a dietary approach known to extend lifespan in animal models. These combined effects may help preserve physiological function, slow the onset of age-associated diseases, and promote healthspan. Nevertheless, the evidence base is still evolving; most current data derive from animal models, in vitro experiments, and limited human trials. Rigorous, long-term, randomized controlled studies are needed to identify optimal dosing, determine long-term safety, and clarify whether glycine can be strategically leveraged as an anti-aging nutrient. If confirmed, glycine’s safety, affordability, and accessibility may make it a compelling option for improving the quality of aging worldwide. https://apcz.umk.pl/QS/article/view/57686glycineaginglongevityoxidative stressinflammationmitochondria |
| spellingShingle | Michalina Wójcikiewicz Julia Kulbacka Witold Czyż Julia Kacperczyk Karol Dziedzic Marta Chuncia-Ileczko Maciej Wojszczyk Damian Zys Piotr Pasek Julia Ryniecka Wiktor Czaja Michał Krzciuk The potential impact of glycine supplementation on the process of aging Quality in Sport glycine aging longevity oxidative stress inflammation mitochondria |
| title | The potential impact of glycine supplementation on the process of aging |
| title_full | The potential impact of glycine supplementation on the process of aging |
| title_fullStr | The potential impact of glycine supplementation on the process of aging |
| title_full_unstemmed | The potential impact of glycine supplementation on the process of aging |
| title_short | The potential impact of glycine supplementation on the process of aging |
| title_sort | potential impact of glycine supplementation on the process of aging |
| topic | glycine aging longevity oxidative stress inflammation mitochondria |
| url | https://apcz.umk.pl/QS/article/view/57686 |
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