mAb production kinetics in CHO batch culture: exploring extracellular and intracellular dynamics
Monoclonal antibodies (mAbs) are complex therapeutic proteins commonly produced by Chinese Hamster Ovary cell culture. Cells are cultivated using a chemically defined medium containing essential nutrients like glucose, amino acids, vitamins, etc., that cells use to grow and produce the target protei...
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| Main Authors: | Alejandro Avilan Garzon, Bruno Ebel, Cédric Paris, Samuel Schneider, David Pfister, Eric Olmos |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1546105/full |
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