Phosphorylated Y14 condensates as a scaffold for DNA double-strand break repair

Phosphorylated Y14 condensates as a scaffold for DNA double-strand break repair

Summary: Various DNA damage response factors form biomolecular condensates at DNA lesions. Targeting phase separation in DNA repair factor assemblies may provide a potential anticancer strategy. An RNA-binding protein, Y14/RBM8A, facilitates the repair of DNA double-strand breaks (DSBs) via its RNA-...

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Bibliographic Details
Main Authors: Chun-Hao Su, Tzu-Wei Chuang, Hsin-Hong Yeh, Chiu-Lun Shen, Pei-Yu Hung, Ying Li, Woan-Yuh Tarn
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:iScience
Subjects:
biochemistry
molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225013343
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