The spectrum of pathogens and their resistance in patients with malignant liver and biliary tract tumors with biliary obstruction after extensive liver resections
The aim of the study to assess the resistance of infectious complication pathogens to antibacterial drugs in patients after major liver resection (MLR) with or without biliary obstruction. Material and methods. A total of 105 patients were assigned to 2 groups: group 1 consisted of 53 patients (7...
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Zaporizhzhia State Medical and Pharmaceutical University
2024-10-01
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| Series: | Zaporožskij Medicinskij Žurnal |
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| Online Access: | http://zmj.zsmu.edu.ua/article/view/310543/303701 |
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| author | V. P. Romaniuk O. H. Kotenko G. A. Solovyova |
| author_facet | V. P. Romaniuk O. H. Kotenko G. A. Solovyova |
| author_sort | V. P. Romaniuk |
| collection | DOAJ |
| description | The aim of the study to assess the resistance of infectious complication pathogens to antibacterial drugs in patients after major liver resection (MLR) with or without biliary obstruction.
Material and methods. A total of 105 patients were assigned to 2 groups: group 1 consisted of 53 patients (7 – with hepatocellular carcinoma (HCC), 28 – with cholangiocarcinoma (CC), 18 – with metastases of colorectal cancer) with biliary obstruction; group 2 – 52 patients (25, 10 and 17, respectively) without biliary obstruction.
Results. A microbiological examination of urine, blood, sputum, bile, pharyngeal and wound samples was performed after MLR.
Conclusions. Patients with HCC and CC with biliary obstruction after MLR had infectious complications in 100.0 % of cases, patients without biliary obstruction – in 25.7%; Gram-positive microorganisms were statistically significantly more often isolated from them: Enterococcus faecalis in 17.1 % (р1,2 = 0.01); gram-negative microorganisms: Escherichia coli in 5.7 % (р1,2 = 0.05), hemolytic Escherichia coli in 5.7 % (р1,2 = 0.05), Pseudomonas aeruginosa in 5.7 % (р1,2 = 0.05); fungi in 8.6 % (р1,2 = 0.04); significantly more often, Enterococcus faecalis was isolated from blood in 5.7 % (р1,2 = 0.05), Enterococcus faecium – from urine in 8.6 % (р1,2 = 0.05), Candida albicans – from wounds in 5.7 % (р1,2 = 0.05) and sputum in 8.6 % (р1,2 = 0.02). |
| format | Article |
| id | doaj-art-a20905fc152f4a6c8f56af0fd4b338de |
| institution | OA Journals |
| issn | 2306-4145 2310-1210 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Zaporožskij Medicinskij Žurnal |
| spelling | doaj-art-a20905fc152f4a6c8f56af0fd4b338de2025-08-20T02:20:44ZengZaporizhzhia State Medical and Pharmaceutical UniversityZaporožskij Medicinskij Žurnal2306-41452310-12102024-10-01265397402https://doi.org/10.14739/2310-1210.2024.5.310543The spectrum of pathogens and their resistance in patients with malignant liver and biliary tract tumors with biliary obstruction after extensive liver resectionsV. P. Romaniuk0https://orcid.org/0000-0002-5476-0326O. H. Kotenko1https://orcid.org/0000-0001-8264-7374G. A. Solovyova2https://orcid.org/0000-0001-8245-3051Medical Center “Universal Clinic “Oberig”, Kyiv, UkraineMedical Center “Universal Clinic “Oberig”, Kyiv, UkraineBogomolets National Medical University, Kyiv, UkraineThe aim of the study to assess the resistance of infectious complication pathogens to antibacterial drugs in patients after major liver resection (MLR) with or without biliary obstruction. Material and methods. A total of 105 patients were assigned to 2 groups: group 1 consisted of 53 patients (7 – with hepatocellular carcinoma (HCC), 28 – with cholangiocarcinoma (CC), 18 – with metastases of colorectal cancer) with biliary obstruction; group 2 – 52 patients (25, 10 and 17, respectively) without biliary obstruction. Results. A microbiological examination of urine, blood, sputum, bile, pharyngeal and wound samples was performed after MLR. Conclusions. Patients with HCC and CC with biliary obstruction after MLR had infectious complications in 100.0 % of cases, patients without biliary obstruction – in 25.7%; Gram-positive microorganisms were statistically significantly more often isolated from them: Enterococcus faecalis in 17.1 % (р1,2 = 0.01); gram-negative microorganisms: Escherichia coli in 5.7 % (р1,2 = 0.05), hemolytic Escherichia coli in 5.7 % (р1,2 = 0.05), Pseudomonas aeruginosa in 5.7 % (р1,2 = 0.05); fungi in 8.6 % (р1,2 = 0.04); significantly more often, Enterococcus faecalis was isolated from blood in 5.7 % (р1,2 = 0.05), Enterococcus faecium – from urine in 8.6 % (р1,2 = 0.05), Candida albicans – from wounds in 5.7 % (р1,2 = 0.05) and sputum in 8.6 % (р1,2 = 0.02).http://zmj.zsmu.edu.ua/article/view/310543/303701liverliver tumorsliver resectionsinfectiouscomplicationsantibiotic resistance microbial |
| spellingShingle | V. P. Romaniuk O. H. Kotenko G. A. Solovyova The spectrum of pathogens and their resistance in patients with malignant liver and biliary tract tumors with biliary obstruction after extensive liver resections Zaporožskij Medicinskij Žurnal liver liver tumors liver resections infectious complications antibiotic resistance microbial |
| title | The spectrum of pathogens and their resistance in patients with malignant liver and biliary tract tumors with biliary obstruction after extensive liver resections |
| title_full | The spectrum of pathogens and their resistance in patients with malignant liver and biliary tract tumors with biliary obstruction after extensive liver resections |
| title_fullStr | The spectrum of pathogens and their resistance in patients with malignant liver and biliary tract tumors with biliary obstruction after extensive liver resections |
| title_full_unstemmed | The spectrum of pathogens and their resistance in patients with malignant liver and biliary tract tumors with biliary obstruction after extensive liver resections |
| title_short | The spectrum of pathogens and their resistance in patients with malignant liver and biliary tract tumors with biliary obstruction after extensive liver resections |
| title_sort | spectrum of pathogens and their resistance in patients with malignant liver and biliary tract tumors with biliary obstruction after extensive liver resections |
| topic | liver liver tumors liver resections infectious complications antibiotic resistance microbial |
| url | http://zmj.zsmu.edu.ua/article/view/310543/303701 |
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