Exploring interhemispheric connectivity using the directional tract density patterns of the corpus callosum
The corpus callosum (CC) is one of the most important interhemispheric white matter tracts that connects interrelated regions of the cerebral cortex. Its disruption has been investigated in previous studies and has been found to play an important role in several neurodegenerative disorders. Currentl...
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Elsevier
2023-06-01
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| Series: | NeuroImage: Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666956023000193 |
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| author | Ali Demir H. Diana Rosas |
| author_facet | Ali Demir H. Diana Rosas |
| author_sort | Ali Demir |
| collection | DOAJ |
| description | The corpus callosum (CC) is one of the most important interhemispheric white matter tracts that connects interrelated regions of the cerebral cortex. Its disruption has been investigated in previous studies and has been found to play an important role in several neurodegenerative disorders. Currently available methods to assess the interhemispheric connectivity of the CC have several limitations: i) they require the a priori identification of specific cortical regions as targets or seeds, ii) they are limited by the characterization of only small components of the structure, primarily voxels that constitute the mid-sagittal slice, and iii) they use global measures of microstructural integrity, which provide only limited characterization. In order to address some of these limitations, we developed a novel method that enables the characterization of white matter tracts covering the structure of CC, from the mid-sagittal plane to corresponding regions of cortex, using directional tract density patterns (dTDPs). We demonstrate that different regions of CC have distinctive dTDPs that reflect a unique regional topology. We conducted a pilot study using this approach to evaluate two different datasets collected from healthy subjects, and we demonstrate that this method is reliable, reproducible, and independent of diffusion acquisition parameters, suggesting its potential applicability to clinical applications. |
| format | Article |
| id | doaj-art-a2076e79cf2e476eb9ffd221ec682b88 |
| institution | OA Journals |
| issn | 2666-9560 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Reports |
| spelling | doaj-art-a2076e79cf2e476eb9ffd221ec682b882025-08-20T01:55:42ZengElsevierNeuroImage: Reports2666-95602023-06-013210017410.1016/j.ynirp.2023.100174Exploring interhemispheric connectivity using the directional tract density patterns of the corpus callosumAli Demir0H. Diana Rosas1Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA; Corresponding author. 149 Thirteenth Street, Suite 10134, Charlestown, MA, 02129, USA.Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USAThe corpus callosum (CC) is one of the most important interhemispheric white matter tracts that connects interrelated regions of the cerebral cortex. Its disruption has been investigated in previous studies and has been found to play an important role in several neurodegenerative disorders. Currently available methods to assess the interhemispheric connectivity of the CC have several limitations: i) they require the a priori identification of specific cortical regions as targets or seeds, ii) they are limited by the characterization of only small components of the structure, primarily voxels that constitute the mid-sagittal slice, and iii) they use global measures of microstructural integrity, which provide only limited characterization. In order to address some of these limitations, we developed a novel method that enables the characterization of white matter tracts covering the structure of CC, from the mid-sagittal plane to corresponding regions of cortex, using directional tract density patterns (dTDPs). We demonstrate that different regions of CC have distinctive dTDPs that reflect a unique regional topology. We conducted a pilot study using this approach to evaluate two different datasets collected from healthy subjects, and we demonstrate that this method is reliable, reproducible, and independent of diffusion acquisition parameters, suggesting its potential applicability to clinical applications.http://www.sciencedirect.com/science/article/pii/S2666956023000193Tract density imagingInterhemispheric connectivityCorpus callosumDirectional tract density patternDiffusionMagnetic resonance imaging |
| spellingShingle | Ali Demir H. Diana Rosas Exploring interhemispheric connectivity using the directional tract density patterns of the corpus callosum NeuroImage: Reports Tract density imaging Interhemispheric connectivity Corpus callosum Directional tract density pattern Diffusion Magnetic resonance imaging |
| title | Exploring interhemispheric connectivity using the directional tract density patterns of the corpus callosum |
| title_full | Exploring interhemispheric connectivity using the directional tract density patterns of the corpus callosum |
| title_fullStr | Exploring interhemispheric connectivity using the directional tract density patterns of the corpus callosum |
| title_full_unstemmed | Exploring interhemispheric connectivity using the directional tract density patterns of the corpus callosum |
| title_short | Exploring interhemispheric connectivity using the directional tract density patterns of the corpus callosum |
| title_sort | exploring interhemispheric connectivity using the directional tract density patterns of the corpus callosum |
| topic | Tract density imaging Interhemispheric connectivity Corpus callosum Directional tract density pattern Diffusion Magnetic resonance imaging |
| url | http://www.sciencedirect.com/science/article/pii/S2666956023000193 |
| work_keys_str_mv | AT alidemir exploringinterhemisphericconnectivityusingthedirectionaltractdensitypatternsofthecorpuscallosum AT hdianarosas exploringinterhemisphericconnectivityusingthedirectionaltractdensitypatternsofthecorpuscallosum |