RETRACTED ARTICLE: Linc-ROR facilitates progression and angiogenesis of hepatocellular carcinoma by modulating DEPDC1 expression
Abstract Linc-ROR have been well-demonstrated to play important roles in cancer progression and angiogenesis. However, the underlying oncogenic mechanism of Linc-ROR in hepatocellular carcinoma is poorly understood. In this study, we demonstrate that Linc-ROR plays an oncogenic role in part through...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2021-11-01
|
| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-021-04303-5 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850042747517403136 |
|---|---|
| author | Chuan Tian Mubalake Abudoureyimu Xinrong Lin Xiaoyuan Chu Rui Wang |
| author_facet | Chuan Tian Mubalake Abudoureyimu Xinrong Lin Xiaoyuan Chu Rui Wang |
| author_sort | Chuan Tian |
| collection | DOAJ |
| description | Abstract Linc-ROR have been well-demonstrated to play important roles in cancer progression and angiogenesis. However, the underlying oncogenic mechanism of Linc-ROR in hepatocellular carcinoma is poorly understood. In this study, we demonstrate that Linc-ROR plays an oncogenic role in part through its positive regulation of DEPDC1 expression. Mechanistically, Linc-ROR acts as competing endogenous RNA to stabilize DEPDC1 mRNA and regulates DEPDC1 mRNA stability by binding HNRNPK. Thus, these findings suggest that function of Linc-ROR-mediated DEPDC1 could predispose hepatocellular carcinoma patients to progression and angiogenesis, and may serve as a potential target for anticancer therapies. |
| format | Article |
| id | doaj-art-a202e052fdef4e218f4dbf8f5fd97f8d |
| institution | DOAJ |
| issn | 2041-4889 |
| language | English |
| publishDate | 2021-11-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death and Disease |
| spelling | doaj-art-a202e052fdef4e218f4dbf8f5fd97f8d2025-08-20T02:55:28ZengNature Publishing GroupCell Death and Disease2041-48892021-11-01121111210.1038/s41419-021-04303-5RETRACTED ARTICLE: Linc-ROR facilitates progression and angiogenesis of hepatocellular carcinoma by modulating DEPDC1 expressionChuan Tian0Mubalake Abudoureyimu1Xinrong Lin2Xiaoyuan Chu3Rui Wang4Department of Medical Oncology, Affiliated Jinling Hospital, Medical School of Nanjing UniversityDepartment of Medical Oncology, Affiliated Jinling Hospital, Medical School of Nanjing UniversityDepartment of Medical Oncology, Affiliated Jinling Hospital, Medical School of Nanjing UniversityDepartment of Medical Oncology, Affiliated Jinling Hospital, Medical School of Nanjing UniversityDepartment of Medical Oncology, Affiliated Jinling Hospital, Medical School of Nanjing UniversityAbstract Linc-ROR have been well-demonstrated to play important roles in cancer progression and angiogenesis. However, the underlying oncogenic mechanism of Linc-ROR in hepatocellular carcinoma is poorly understood. In this study, we demonstrate that Linc-ROR plays an oncogenic role in part through its positive regulation of DEPDC1 expression. Mechanistically, Linc-ROR acts as competing endogenous RNA to stabilize DEPDC1 mRNA and regulates DEPDC1 mRNA stability by binding HNRNPK. Thus, these findings suggest that function of Linc-ROR-mediated DEPDC1 could predispose hepatocellular carcinoma patients to progression and angiogenesis, and may serve as a potential target for anticancer therapies.https://doi.org/10.1038/s41419-021-04303-5 |
| spellingShingle | Chuan Tian Mubalake Abudoureyimu Xinrong Lin Xiaoyuan Chu Rui Wang RETRACTED ARTICLE: Linc-ROR facilitates progression and angiogenesis of hepatocellular carcinoma by modulating DEPDC1 expression Cell Death and Disease |
| title | RETRACTED ARTICLE: Linc-ROR facilitates progression and angiogenesis of hepatocellular carcinoma by modulating DEPDC1 expression |
| title_full | RETRACTED ARTICLE: Linc-ROR facilitates progression and angiogenesis of hepatocellular carcinoma by modulating DEPDC1 expression |
| title_fullStr | RETRACTED ARTICLE: Linc-ROR facilitates progression and angiogenesis of hepatocellular carcinoma by modulating DEPDC1 expression |
| title_full_unstemmed | RETRACTED ARTICLE: Linc-ROR facilitates progression and angiogenesis of hepatocellular carcinoma by modulating DEPDC1 expression |
| title_short | RETRACTED ARTICLE: Linc-ROR facilitates progression and angiogenesis of hepatocellular carcinoma by modulating DEPDC1 expression |
| title_sort | retracted article linc ror facilitates progression and angiogenesis of hepatocellular carcinoma by modulating depdc1 expression |
| url | https://doi.org/10.1038/s41419-021-04303-5 |
| work_keys_str_mv | AT chuantian retractedarticlelincrorfacilitatesprogressionandangiogenesisofhepatocellularcarcinomabymodulatingdepdc1expression AT mubalakeabudoureyimu retractedarticlelincrorfacilitatesprogressionandangiogenesisofhepatocellularcarcinomabymodulatingdepdc1expression AT xinronglin retractedarticlelincrorfacilitatesprogressionandangiogenesisofhepatocellularcarcinomabymodulatingdepdc1expression AT xiaoyuanchu retractedarticlelincrorfacilitatesprogressionandangiogenesisofhepatocellularcarcinomabymodulatingdepdc1expression AT ruiwang retractedarticlelincrorfacilitatesprogressionandangiogenesisofhepatocellularcarcinomabymodulatingdepdc1expression |