Ileitis in Adult Multisystem Inflammatory Syndrome: A Case Report
Multisystem inflammatory syndrome (MIS) can manifest with nonspecific gastrointestinal symptoms, fever, shock, and cardiovascular dysfunction. Compared with children, MIS in adults (MIS-A) is rare. We present a definitive case of MIS-A (based on the Brighton criteria) in a young adult with fever, er...
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| Format: | Article |
| Language: | English |
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American College of Physicians
2022-07-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2022.0206 |
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| author | Michelle Forson Michael Aljadah Lindsay Hammons Alexandra Harrington Poonam Beniwal-Patel Anna Johnson Eric Krumpelbeck Joshua Field Erin Strong Joshua Pearl Adrian Umpierrez Jayshil J. Patel |
| author_facet | Michelle Forson Michael Aljadah Lindsay Hammons Alexandra Harrington Poonam Beniwal-Patel Anna Johnson Eric Krumpelbeck Joshua Field Erin Strong Joshua Pearl Adrian Umpierrez Jayshil J. Patel |
| author_sort | Michelle Forson |
| collection | DOAJ |
| description | Multisystem inflammatory syndrome (MIS) can manifest with nonspecific gastrointestinal symptoms, fever, shock, and cardiovascular dysfunction. Compared with children, MIS in adults (MIS-A) is rare. We present a definitive case of MIS-A (based on the Brighton criteria) in a young adult with fever, erythematous rash, and prominent gastrointestinal (ileitis) features, elevated inflammatory markers with evidence of cardiac involvement, and renal injury 4 weeks after confirmed SARS-CoV-2 infection. We highlight the histopathologic features from an ileal biopsy, which demonstrated reactive lymphocytic infiltrates. To our knowledge, this is the first report describing intestinal histopathologic findings in MIS-A. |
| format | Article |
| id | doaj-art-a2029667166c45ce9000ccd4dd8d9ffc |
| institution | DOAJ |
| issn | 2767-7664 |
| language | English |
| publishDate | 2022-07-01 |
| publisher | American College of Physicians |
| record_format | Article |
| series | Annals of Internal Medicine: Clinical Cases |
| spelling | doaj-art-a2029667166c45ce9000ccd4dd8d9ffc2025-08-20T03:18:49ZengAmerican College of PhysiciansAnnals of Internal Medicine: Clinical Cases2767-76642022-07-011510.7326/aimcc.2022.0206Ileitis in Adult Multisystem Inflammatory Syndrome: A Case ReportMichelle Forson0Michael Aljadah1Lindsay Hammons2Alexandra Harrington3Poonam Beniwal-Patel4Anna Johnson5Eric Krumpelbeck6Joshua Field7Erin Strong8Joshua Pearl9Adrian Umpierrez10Jayshil J. Patel111Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Froedtert and Medical College of Wisconsin, Milwaukee, Wisconsin2Department of Medicine, Medical College of Wisconsin, Milwaukee Wisconsin3Department of Medicine, Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin4Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin5Department of Medicine, Division of Gastroenterology, Medical College of Wisconsin, Milwaukee, Wisconsin2Department of Medicine, Medical College of Wisconsin, Milwaukee Wisconsin2Department of Medicine, Medical College of Wisconsin, Milwaukee Wisconsin3Department of Medicine, Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin6Department of Surgery, Division of Acute Care and Trauma Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin6Department of Surgery, Division of Acute Care and Trauma Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin7Department of Medicine, Division of Internal Medicine, Section of Hospital Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin1Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Froedtert and Medical College of Wisconsin, Milwaukee, WisconsinMultisystem inflammatory syndrome (MIS) can manifest with nonspecific gastrointestinal symptoms, fever, shock, and cardiovascular dysfunction. Compared with children, MIS in adults (MIS-A) is rare. We present a definitive case of MIS-A (based on the Brighton criteria) in a young adult with fever, erythematous rash, and prominent gastrointestinal (ileitis) features, elevated inflammatory markers with evidence of cardiac involvement, and renal injury 4 weeks after confirmed SARS-CoV-2 infection. We highlight the histopathologic features from an ileal biopsy, which demonstrated reactive lymphocytic infiltrates. To our knowledge, this is the first report describing intestinal histopathologic findings in MIS-A.https://www.acpjournals.org/doi/10.7326/aimcc.2022.0206 |
| spellingShingle | Michelle Forson Michael Aljadah Lindsay Hammons Alexandra Harrington Poonam Beniwal-Patel Anna Johnson Eric Krumpelbeck Joshua Field Erin Strong Joshua Pearl Adrian Umpierrez Jayshil J. Patel Ileitis in Adult Multisystem Inflammatory Syndrome: A Case Report Annals of Internal Medicine: Clinical Cases |
| title | Ileitis in Adult Multisystem Inflammatory Syndrome: A Case Report |
| title_full | Ileitis in Adult Multisystem Inflammatory Syndrome: A Case Report |
| title_fullStr | Ileitis in Adult Multisystem Inflammatory Syndrome: A Case Report |
| title_full_unstemmed | Ileitis in Adult Multisystem Inflammatory Syndrome: A Case Report |
| title_short | Ileitis in Adult Multisystem Inflammatory Syndrome: A Case Report |
| title_sort | ileitis in adult multisystem inflammatory syndrome a case report |
| url | https://www.acpjournals.org/doi/10.7326/aimcc.2022.0206 |
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