A visual cortical-lateral posterior thalamic nucleus circuit regulates depressive-like behaviors in male mice
Abstract Depression, a prevalent psychiatric disorder of ambiguous etiology and high heterogeneity, has been recently linked to the primary visual cortex (V1). However, the precise circuits mediating the impact of V1 on depressive-like behaviors are poorly understood. Here, we demonstrate that the V...
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Nature Portfolio
2025-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-55600-4 |
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| author | Fangfang Wu Chenxi Gu Rui Xu Junwei Ma Lei Gao Youjiao Zhang Siyuan Bu Qingbo Lu Te Zhao Yijun Han Chen Guo Yihui Cui Jianhua Ding Gang Hu Zhijun Zhang |
| author_facet | Fangfang Wu Chenxi Gu Rui Xu Junwei Ma Lei Gao Youjiao Zhang Siyuan Bu Qingbo Lu Te Zhao Yijun Han Chen Guo Yihui Cui Jianhua Ding Gang Hu Zhijun Zhang |
| author_sort | Fangfang Wu |
| collection | DOAJ |
| description | Abstract Depression, a prevalent psychiatric disorder of ambiguous etiology and high heterogeneity, has been recently linked to the primary visual cortex (V1). However, the precise circuits mediating the impact of V1 on depressive-like behaviors are poorly understood. Here, we demonstrate that the V1, specifically the lateral posterior nucleus of the thalamus (LP)-projecting V1 glutamatergic subpopulation (GluV1→LP neurons), shows reduced activity after chronic restraint stress (CRS) in male mice, leading to depressive-like behaviors. Optogenetic or chemogenetic activation of these neurons ameliorated depressive-like behaviors in CRS-depressed mice, whereas reducing activity exacerbated these behaviors. This reduction in GluV1→LP neurons activity was predominantly due to a decrease in the guanine nucleotide-binding protein subunit gamma-4 (Gγ4). Overexpression of Gγ4 in the GluV1→LP neurons produced antidepressant-like effects, suggesting that Gγ4 is a crucial regulator of mood. Collectively, these results reveal a V1→LP circuit that modulates depressive-like behaviors, suggesting potential targets for therapeutic interventions. |
| format | Article |
| id | doaj-art-a1fb3570dde449a3848586448359d4ce |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-a1fb3570dde449a3848586448359d4ce2025-02-09T12:44:41ZengNature PortfolioNature Communications2041-17232025-02-0116111710.1038/s41467-024-55600-4A visual cortical-lateral posterior thalamic nucleus circuit regulates depressive-like behaviors in male miceFangfang Wu0Chenxi Gu1Rui Xu2Junwei Ma3Lei Gao4Youjiao Zhang5Siyuan Bu6Qingbo Lu7Te Zhao8Yijun Han9Chen Guo10Yihui Cui11Jianhua Ding12Gang Hu13Zhijun Zhang14Department of Pharmacology, School of Medicine, Nanjing University of Chinese MedicineJiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical UniversityDepartment of Pharmacology, School of Medicine, Nanjing University of Chinese MedicineDepartment of Pharmacology, School of Medicine, Nanjing University of Chinese MedicineDepartment of Pharmacology, School of Medicine, Nanjing University of Chinese MedicineDepartment of Pharmacology, School of Medicine, Nanjing University of Chinese MedicineDepartment of Neurology, Affiliated Zhongda Hospital and Jiangsu Provincial Medical Key Discipline, School of Medicine, Southeast UniversityDepartment of Neurology, Affiliated Zhongda Hospital and Jiangsu Provincial Medical Key Discipline, School of Medicine, Southeast UniversityShenzhen Key Laboratory of Precision Diagnosis and Treatment of Depression, Department of Mental Health and Public Health, Faculty of Life and Health Sciences, Shenzhen University of Advanced Technology, Shenzhen Institute of Advanced Technology, Chinese Academy of SciencesShenzhen Key Laboratory of Precision Diagnosis and Treatment of Depression, Department of Mental Health and Public Health, Faculty of Life and Health Sciences, Shenzhen University of Advanced Technology, Shenzhen Institute of Advanced Technology, Chinese Academy of SciencesDepartment of Neurology of Sir Run Run Shaw Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of MedicineDepartment of Neurology of Sir Run Run Shaw Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of MedicineJiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical UniversityDepartment of Pharmacology, School of Medicine, Nanjing University of Chinese MedicineDepartment of Neurology, Affiliated Zhongda Hospital and Jiangsu Provincial Medical Key Discipline, School of Medicine, Southeast UniversityAbstract Depression, a prevalent psychiatric disorder of ambiguous etiology and high heterogeneity, has been recently linked to the primary visual cortex (V1). However, the precise circuits mediating the impact of V1 on depressive-like behaviors are poorly understood. Here, we demonstrate that the V1, specifically the lateral posterior nucleus of the thalamus (LP)-projecting V1 glutamatergic subpopulation (GluV1→LP neurons), shows reduced activity after chronic restraint stress (CRS) in male mice, leading to depressive-like behaviors. Optogenetic or chemogenetic activation of these neurons ameliorated depressive-like behaviors in CRS-depressed mice, whereas reducing activity exacerbated these behaviors. This reduction in GluV1→LP neurons activity was predominantly due to a decrease in the guanine nucleotide-binding protein subunit gamma-4 (Gγ4). Overexpression of Gγ4 in the GluV1→LP neurons produced antidepressant-like effects, suggesting that Gγ4 is a crucial regulator of mood. Collectively, these results reveal a V1→LP circuit that modulates depressive-like behaviors, suggesting potential targets for therapeutic interventions.https://doi.org/10.1038/s41467-024-55600-4 |
| spellingShingle | Fangfang Wu Chenxi Gu Rui Xu Junwei Ma Lei Gao Youjiao Zhang Siyuan Bu Qingbo Lu Te Zhao Yijun Han Chen Guo Yihui Cui Jianhua Ding Gang Hu Zhijun Zhang A visual cortical-lateral posterior thalamic nucleus circuit regulates depressive-like behaviors in male mice Nature Communications |
| title | A visual cortical-lateral posterior thalamic nucleus circuit regulates depressive-like behaviors in male mice |
| title_full | A visual cortical-lateral posterior thalamic nucleus circuit regulates depressive-like behaviors in male mice |
| title_fullStr | A visual cortical-lateral posterior thalamic nucleus circuit regulates depressive-like behaviors in male mice |
| title_full_unstemmed | A visual cortical-lateral posterior thalamic nucleus circuit regulates depressive-like behaviors in male mice |
| title_short | A visual cortical-lateral posterior thalamic nucleus circuit regulates depressive-like behaviors in male mice |
| title_sort | visual cortical lateral posterior thalamic nucleus circuit regulates depressive like behaviors in male mice |
| url | https://doi.org/10.1038/s41467-024-55600-4 |
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