Ultra‐low LOD H2O2 Sensor Based on Synergistic Nernst Potential Effect
Abstract The food processing industry and biomedical science research are relying on the low limit of detection (LOD) for hydrogen peroxide (H2O2). Organic electrochemical transistors (OECTs) are excellent for biochemical sensing applications due to their excellent signal amplification capability. T...
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Wiley
2025-07-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202413898 |
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| author | Zhaoqun Wang Wen Gao Xiaorong Niu Yuhang Liu Zichen Jin Fan Zhang Zhengdong Cheng Xiaoning Jiang Wendong Zhang Ting Wang Jianlong Ji Xiaojie Chai Shengbo Sang |
| author_facet | Zhaoqun Wang Wen Gao Xiaorong Niu Yuhang Liu Zichen Jin Fan Zhang Zhengdong Cheng Xiaoning Jiang Wendong Zhang Ting Wang Jianlong Ji Xiaojie Chai Shengbo Sang |
| author_sort | Zhaoqun Wang |
| collection | DOAJ |
| description | Abstract The food processing industry and biomedical science research are relying on the low limit of detection (LOD) for hydrogen peroxide (H2O2). Organic electrochemical transistors (OECTs) are excellent for biochemical sensing applications due to their excellent signal amplification capability. The paper describes a way of detecting H2O2 through the use of stacked poly(3,4‐ethylenedioxythiophene): bromothymol blue (PEDOT: BTB)/poly(3,4‐ethylenedioxythiophene): polystyrene sulfonate (PEDOT: PSS) as the semiconducting channel of the OECT. The H2O2 sensor presents an ultra‐low LOD, down to 1.8 × 10−12 M, due to the synergistic effect of the Nernst potential generated by the platinum gate electrode catalyzing H2O2 and the Nernst potential generated by the interaction between BTB molecules and hydrogen ions, the by‐product of H2O2 catalysis. A microsystemwith a signal processing circuit and a mobile app for the sensor has been developed, and they are then tested on commercial milk samples to verify their reliability. Since the majority of enzyme‐catalyzed reactions generate or use H2O2 in biochemical reactions, the methodology is applicable not only to the detection of H2O2 but also to the detection of analytes based on enzyme‐catalyzed reactions. For demonstration, glucose detection with a LOD of down to 8.82 × 10−11 M is also presented. |
| format | Article |
| id | doaj-art-a1f8fa5f0b4d46aca5c5509fe6f967ba |
| institution | DOAJ |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-a1f8fa5f0b4d46aca5c5509fe6f967ba2025-08-20T03:04:57ZengWileyAdvanced Science2198-38442025-07-011226n/an/a10.1002/advs.202413898Ultra‐low LOD H2O2 Sensor Based on Synergistic Nernst Potential EffectZhaoqun Wang0Wen Gao1Xiaorong Niu2Yuhang Liu3Zichen Jin4Fan Zhang5Zhengdong Cheng6Xiaoning Jiang7Wendong Zhang8Ting Wang9Jianlong Ji10Xiaojie Chai11Shengbo Sang12College of Integrated Circuits Taiyuan University of Technology Taiyuan 030024 ChinaXinzhou Comprehensive Inspection and Testing Center Xinzhou 034000 ChinaCollege of Integrated Circuits Taiyuan University of Technology Taiyuan 030024 ChinaCollege of Integrated Circuits Taiyuan University of Technology Taiyuan 030024 ChinaSchool of Aeronautics and Astronautics University of Electronic Science and Technology of China Chengdu 611731 ChinaCollege of Integrated Circuits Taiyuan University of Technology Taiyuan 030024 ChinaCollege of Chemical and Biological Engineering Zhejiang University Hangzhou 310058 ChinaDepartment of Mechanical and Aerospace Engineering North Carolina State University Raleigh 27695 USACollege of Integrated Circuits Taiyuan University of Technology Taiyuan 030024 ChinaState Key Laboratory of Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials (IAM) Nanjing University of Posts and Telecommunications Nanjing 210023 ChinaCollege of Integrated Circuits Taiyuan University of Technology Taiyuan 030024 ChinaCollege of Integrated Circuits Taiyuan University of Technology Taiyuan 030024 ChinaCollege of Integrated Circuits Taiyuan University of Technology Taiyuan 030024 ChinaAbstract The food processing industry and biomedical science research are relying on the low limit of detection (LOD) for hydrogen peroxide (H2O2). Organic electrochemical transistors (OECTs) are excellent for biochemical sensing applications due to their excellent signal amplification capability. The paper describes a way of detecting H2O2 through the use of stacked poly(3,4‐ethylenedioxythiophene): bromothymol blue (PEDOT: BTB)/poly(3,4‐ethylenedioxythiophene): polystyrene sulfonate (PEDOT: PSS) as the semiconducting channel of the OECT. The H2O2 sensor presents an ultra‐low LOD, down to 1.8 × 10−12 M, due to the synergistic effect of the Nernst potential generated by the platinum gate electrode catalyzing H2O2 and the Nernst potential generated by the interaction between BTB molecules and hydrogen ions, the by‐product of H2O2 catalysis. A microsystemwith a signal processing circuit and a mobile app for the sensor has been developed, and they are then tested on commercial milk samples to verify their reliability. Since the majority of enzyme‐catalyzed reactions generate or use H2O2 in biochemical reactions, the methodology is applicable not only to the detection of H2O2 but also to the detection of analytes based on enzyme‐catalyzed reactions. For demonstration, glucose detection with a LOD of down to 8.82 × 10−11 M is also presented.https://doi.org/10.1002/advs.202413898hydrogen peroxide detectionorganic electrochemical transistorsultralow limit of detection |
| spellingShingle | Zhaoqun Wang Wen Gao Xiaorong Niu Yuhang Liu Zichen Jin Fan Zhang Zhengdong Cheng Xiaoning Jiang Wendong Zhang Ting Wang Jianlong Ji Xiaojie Chai Shengbo Sang Ultra‐low LOD H2O2 Sensor Based on Synergistic Nernst Potential Effect Advanced Science hydrogen peroxide detection organic electrochemical transistors ultralow limit of detection |
| title | Ultra‐low LOD H2O2 Sensor Based on Synergistic Nernst Potential Effect |
| title_full | Ultra‐low LOD H2O2 Sensor Based on Synergistic Nernst Potential Effect |
| title_fullStr | Ultra‐low LOD H2O2 Sensor Based on Synergistic Nernst Potential Effect |
| title_full_unstemmed | Ultra‐low LOD H2O2 Sensor Based on Synergistic Nernst Potential Effect |
| title_short | Ultra‐low LOD H2O2 Sensor Based on Synergistic Nernst Potential Effect |
| title_sort | ultra low lod h2o2 sensor based on synergistic nernst potential effect |
| topic | hydrogen peroxide detection organic electrochemical transistors ultralow limit of detection |
| url | https://doi.org/10.1002/advs.202413898 |
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