Photocatalyzed elaboration of antibody-based bioconjugates
Antibody–drug conjugates (ADCs) represent a promising class of targeted therapeutics, combining the specificity of antibodies with the potency of cytotoxic drugs to enhance therapeutic efficacy while minimizing off-target effects. The development of new chemical methods for bioconjugation is essenti...
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2025-03-01
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| Series: | Beilstein Journal of Organic Chemistry |
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| Online Access: | https://doi.org/10.3762/bjoc.21.49 |
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| author | Marine Le Stum Eugénie Romero Gary A. Molander |
| author_facet | Marine Le Stum Eugénie Romero Gary A. Molander |
| author_sort | Marine Le Stum |
| collection | DOAJ |
| description | Antibody–drug conjugates (ADCs) represent a promising class of targeted therapeutics, combining the specificity of antibodies with the potency of cytotoxic drugs to enhance therapeutic efficacy while minimizing off-target effects. The development of new chemical methods for bioconjugation is essential to generate ADCs and to optimize their stability, efficacy, and safety. Traditional conjugation methods often face challenges related to site-selectivity and heterogeneous product mixtures, highlighting the need to develop new, innovative chemical strategies. Photoredox chemistry emerges as a powerful tool in this context, enabling precise, mild, and selective modifications of peptides and proteins. By harnessing light to drive chemical transformations, photoredox techniques can facilitate the synthesis of antibody bioconjugates. This perspective will discuss the drive to develop and empower photoredox methods applied to antibody functionalization. |
| format | Article |
| id | doaj-art-a1f7d540fcb64abb997133e0a37a7e41 |
| institution | DOAJ |
| issn | 1860-5397 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj-art-a1f7d540fcb64abb997133e0a37a7e412025-08-20T03:09:28ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972025-03-0121161662910.3762/bjoc.21.491860-5397-21-49Photocatalyzed elaboration of antibody-based bioconjugatesMarine Le Stum0Eugénie Romero1Gary A. Molander2Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SCBM, 91191 Gif-Sur-Yvette, France Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SCBM, 91191 Gif-Sur-Yvette, France Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SCBM, 91191 Gif-Sur-Yvette, France Antibody–drug conjugates (ADCs) represent a promising class of targeted therapeutics, combining the specificity of antibodies with the potency of cytotoxic drugs to enhance therapeutic efficacy while minimizing off-target effects. The development of new chemical methods for bioconjugation is essential to generate ADCs and to optimize their stability, efficacy, and safety. Traditional conjugation methods often face challenges related to site-selectivity and heterogeneous product mixtures, highlighting the need to develop new, innovative chemical strategies. Photoredox chemistry emerges as a powerful tool in this context, enabling precise, mild, and selective modifications of peptides and proteins. By harnessing light to drive chemical transformations, photoredox techniques can facilitate the synthesis of antibody bioconjugates. This perspective will discuss the drive to develop and empower photoredox methods applied to antibody functionalization.https://doi.org/10.3762/bjoc.21.49antibodiesbioconjugationbioorthogonalitychemoselectivitylate-stage functionalizationphotochemistry |
| spellingShingle | Marine Le Stum Eugénie Romero Gary A. Molander Photocatalyzed elaboration of antibody-based bioconjugates Beilstein Journal of Organic Chemistry antibodies bioconjugation bioorthogonality chemoselectivity late-stage functionalization photochemistry |
| title | Photocatalyzed elaboration of antibody-based bioconjugates |
| title_full | Photocatalyzed elaboration of antibody-based bioconjugates |
| title_fullStr | Photocatalyzed elaboration of antibody-based bioconjugates |
| title_full_unstemmed | Photocatalyzed elaboration of antibody-based bioconjugates |
| title_short | Photocatalyzed elaboration of antibody-based bioconjugates |
| title_sort | photocatalyzed elaboration of antibody based bioconjugates |
| topic | antibodies bioconjugation bioorthogonality chemoselectivity late-stage functionalization photochemistry |
| url | https://doi.org/10.3762/bjoc.21.49 |
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