Challenges and Applications of Bio-Sniffers for Monitoring Volatile Organic Compounds in Medical Diagnostics
Bio-sniffers represent a novel detection technology that demonstrates significant potential in medical diagnostics. Specifically, they assess disease conditions and metabolic status through the detection of volatile organic compounds (VOCs) in exhaled breath. Unlike conventional methods such as gas...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-04-01
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| Series: | Chemosensors |
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| Online Access: | https://www.mdpi.com/2227-9040/13/4/127 |
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| author | Yang Wang Xunda Zhou Siying Mao Shiwei Chen Zhenzhong Guo |
| author_facet | Yang Wang Xunda Zhou Siying Mao Shiwei Chen Zhenzhong Guo |
| author_sort | Yang Wang |
| collection | DOAJ |
| description | Bio-sniffers represent a novel detection technology that demonstrates significant potential in medical diagnostics. Specifically, they assess disease conditions and metabolic status through the detection of volatile organic compounds (VOCs) in exhaled breath. Unlike conventional methods such as gas chromatography-mass spectrometry (GC-MS) and gas chromatography time-of-flight mass spectrometry (GC-TOF-MS), bio-sniffers provide rapid, sensitive, and portable detection capabilities. In this review, we examine the metabolic pathways and detection methods of specific VOCs in the human body, and their roles as disease biomarkers, and focus on the detection principles, performance characteristics, and medical applications of two bio-sniffer types: electrical and optical sensors. Finally, we systematically discuss the current challenges facing bio-sniffers in VOC monitoring, outline future development directions, and provide suggestions for improving sensitivity and reducing environmental interference. |
| format | Article |
| id | doaj-art-a1f735bd635b4239a1f2ce30765522d4 |
| institution | OA Journals |
| issn | 2227-9040 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemosensors |
| spelling | doaj-art-a1f735bd635b4239a1f2ce30765522d42025-08-20T02:28:40ZengMDPI AGChemosensors2227-90402025-04-0113412710.3390/chemosensors13040127Challenges and Applications of Bio-Sniffers for Monitoring Volatile Organic Compounds in Medical DiagnosticsYang Wang0Xunda Zhou1Siying Mao2Shiwei Chen3Zhenzhong Guo4Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Public Health, Faculty of Medicine, Wuhan University of Science and Technology, Wuhan 430065, ChinaHubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Public Health, Faculty of Medicine, Wuhan University of Science and Technology, Wuhan 430065, ChinaHubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Public Health, Faculty of Medicine, Wuhan University of Science and Technology, Wuhan 430065, ChinaHubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Public Health, Faculty of Medicine, Wuhan University of Science and Technology, Wuhan 430065, ChinaHubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Public Health, Faculty of Medicine, Wuhan University of Science and Technology, Wuhan 430065, ChinaBio-sniffers represent a novel detection technology that demonstrates significant potential in medical diagnostics. Specifically, they assess disease conditions and metabolic status through the detection of volatile organic compounds (VOCs) in exhaled breath. Unlike conventional methods such as gas chromatography-mass spectrometry (GC-MS) and gas chromatography time-of-flight mass spectrometry (GC-TOF-MS), bio-sniffers provide rapid, sensitive, and portable detection capabilities. In this review, we examine the metabolic pathways and detection methods of specific VOCs in the human body, and their roles as disease biomarkers, and focus on the detection principles, performance characteristics, and medical applications of two bio-sniffer types: electrical and optical sensors. Finally, we systematically discuss the current challenges facing bio-sniffers in VOC monitoring, outline future development directions, and provide suggestions for improving sensitivity and reducing environmental interference.https://www.mdpi.com/2227-9040/13/4/127breath analysisbio-snifferbiomarkervolatile organic compounds (VOCs)medical diagnosis |
| spellingShingle | Yang Wang Xunda Zhou Siying Mao Shiwei Chen Zhenzhong Guo Challenges and Applications of Bio-Sniffers for Monitoring Volatile Organic Compounds in Medical Diagnostics Chemosensors breath analysis bio-sniffer biomarker volatile organic compounds (VOCs) medical diagnosis |
| title | Challenges and Applications of Bio-Sniffers for Monitoring Volatile Organic Compounds in Medical Diagnostics |
| title_full | Challenges and Applications of Bio-Sniffers for Monitoring Volatile Organic Compounds in Medical Diagnostics |
| title_fullStr | Challenges and Applications of Bio-Sniffers for Monitoring Volatile Organic Compounds in Medical Diagnostics |
| title_full_unstemmed | Challenges and Applications of Bio-Sniffers for Monitoring Volatile Organic Compounds in Medical Diagnostics |
| title_short | Challenges and Applications of Bio-Sniffers for Monitoring Volatile Organic Compounds in Medical Diagnostics |
| title_sort | challenges and applications of bio sniffers for monitoring volatile organic compounds in medical diagnostics |
| topic | breath analysis bio-sniffer biomarker volatile organic compounds (VOCs) medical diagnosis |
| url | https://www.mdpi.com/2227-9040/13/4/127 |
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