The genetic diversity of Strongyloides papillosus in Pakistani goats revealed by whole genome sequencing
Abstract Background Strongyloides nematodes are livestock parasites, and Strongyloides papillosus infecting ruminant livestock can cause disease. Recent genomic analysis of several Strongyloides species is now facilitating population genomic analyses of natural Strongyloides infections, for example...
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BMC
2024-12-01
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| Series: | Parasites & Vectors |
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| Online Access: | https://doi.org/10.1186/s13071-024-06626-6 |
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| author | Kiran Afshan Yuchen Liu Mark Viney |
| author_facet | Kiran Afshan Yuchen Liu Mark Viney |
| author_sort | Kiran Afshan |
| collection | DOAJ |
| description | Abstract Background Strongyloides nematodes are livestock parasites, and Strongyloides papillosus infecting ruminant livestock can cause disease. Recent genomic analysis of several Strongyloides species is now facilitating population genomic analyses of natural Strongyloides infections, for example finding that Strongyloides ratti in wild UK rats exists as an assemblage of long-lived, asexual lineages. Methods Here we have initiated an investigation into the population genomics of S. papillosus in goats in Pakistan. We sampled Strongyloides from goat faeces and then whole genome sequenced individual larvae. Results We find that S. papillosus is common, with a prevalence of 28%; that the population is genetically diverse and that individual goats commonly have mixed-genotype infections, and that there is evidence of admixture in only ca. 20% of worms. Conclusions These results now provoke further questions about the host range of different S. papillosus genotypes that can be investigated by further population genomic analyses in the future. Graphical Abstract |
| format | Article |
| id | doaj-art-a1f2e83476a84665b7efd206761c2f06 |
| institution | DOAJ |
| issn | 1756-3305 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Parasites & Vectors |
| spelling | doaj-art-a1f2e83476a84665b7efd206761c2f062025-08-20T02:40:21ZengBMCParasites & Vectors1756-33052024-12-011711710.1186/s13071-024-06626-6The genetic diversity of Strongyloides papillosus in Pakistani goats revealed by whole genome sequencingKiran Afshan0Yuchen Liu1Mark Viney2Department of Zoology, Faculty of Biological Sciences, Quaid-i-Azam UniversityDepartment of Evolution, Ecology and Behaviour, University of LiverpoolDepartment of Evolution, Ecology and Behaviour, University of LiverpoolAbstract Background Strongyloides nematodes are livestock parasites, and Strongyloides papillosus infecting ruminant livestock can cause disease. Recent genomic analysis of several Strongyloides species is now facilitating population genomic analyses of natural Strongyloides infections, for example finding that Strongyloides ratti in wild UK rats exists as an assemblage of long-lived, asexual lineages. Methods Here we have initiated an investigation into the population genomics of S. papillosus in goats in Pakistan. We sampled Strongyloides from goat faeces and then whole genome sequenced individual larvae. Results We find that S. papillosus is common, with a prevalence of 28%; that the population is genetically diverse and that individual goats commonly have mixed-genotype infections, and that there is evidence of admixture in only ca. 20% of worms. Conclusions These results now provoke further questions about the host range of different S. papillosus genotypes that can be investigated by further population genomic analyses in the future. Graphical Abstracthttps://doi.org/10.1186/s13071-024-06626-6StrongyloidesStrongyloides papillosusPopulation genomics |
| spellingShingle | Kiran Afshan Yuchen Liu Mark Viney The genetic diversity of Strongyloides papillosus in Pakistani goats revealed by whole genome sequencing Parasites & Vectors Strongyloides Strongyloides papillosus Population genomics |
| title | The genetic diversity of Strongyloides papillosus in Pakistani goats revealed by whole genome sequencing |
| title_full | The genetic diversity of Strongyloides papillosus in Pakistani goats revealed by whole genome sequencing |
| title_fullStr | The genetic diversity of Strongyloides papillosus in Pakistani goats revealed by whole genome sequencing |
| title_full_unstemmed | The genetic diversity of Strongyloides papillosus in Pakistani goats revealed by whole genome sequencing |
| title_short | The genetic diversity of Strongyloides papillosus in Pakistani goats revealed by whole genome sequencing |
| title_sort | genetic diversity of strongyloides papillosus in pakistani goats revealed by whole genome sequencing |
| topic | Strongyloides Strongyloides papillosus Population genomics |
| url | https://doi.org/10.1186/s13071-024-06626-6 |
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