Single-cell profiling reveals periosteal signatures of impaired periosteal cells proliferation in a drill-hole model of type 2 diabetes

Single-cell profiling reveals periosteal signatures of impaired periosteal cells proliferation in a drill-hole model of type 2 diabetes

Abstract Type 2 diabetes mellitus (T2DM) is associated with an elevated fracture risk and impaired healing, but the periosteum’s role in delayed repair remains unclear. In db/db mice, both trabecular and cortical bone mass were reduced, with single-cell RNA sequencing revealing downregulation of the...

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Bibliographic Details
Main Authors: Xing Ji, Jiahao Luo, Yangxun He, Xinhua Hu, Taotao Xu, Yuanlong Wang, Sijun Pan, Jiali Yao, Weiwei Hu, Ximei Wu
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Cell Communication and Signaling
Subjects:
Periosteum
T2DM
Delayed fracture healing
Fibrinogen-like Protein 2
ScRNA-seq
Online Access:https://doi.org/10.1186/s12964-025-02349-y
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