Tyrosine phosphatase Shp2 accelerated the progression of dilated cardiomyopathy via upregulating NF-κB/Src/FAK signaling induced ROS and mitophagy

Tyrosine phosphatase Shp2 accelerated the progression of dilated cardiomyopathy via upregulating NF-κB/Src/FAK signaling induced ROS and mitophagy

Abstract The purpose of this study was to investigate whether tyrosine phosphatase Shp2 can promote the progression of dilated cardiomyopathy by upregulating intracellular oxidative stress and subsequently promoting mitophagy. Macrophage-specific Shp2 knockout mice were cultured and a dilated cardio...

Full description

Saved in:
Bibliographic Details
Main Authors: Jingxia Hao, Hua Wang, Bo Li, Jingshi Chen, Wenlu Wang, Yingxue Wang, Yingqian Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
BMMs
SHP-2
Dilated cardiomyopathy
Oxidative stress
Mitophagy
Online Access:https://doi.org/10.1038/s41598-025-04375-9
Tags: Add Tag
No Tags, Be the first to tag this record!
Be the first to leave a comment!
You must be logged in first

Similar Items