SNP-SNP Interactions and Gastric Cancer Susceptibility in Ardabil Province
Background: Gastric cancer is a type of malignancy that affects the digestive system. Symptoms of gastric cancer are often hard to detect in the early stages, and become more noticeable only after cancer cells have grown inside the stomach wall and spread to other parts of the body. The genetic code...
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Ardabil University of Medical Sciences
2024-10-01
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| Series: | Journal of Ardabil University of Medical Sciences |
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| Online Access: | http://jarums.arums.ac.ir/article-1-2429-en.pdf |
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| author | Homa Akhavan Aghghaleh Najmeh Ranji Hadi Habibollahi |
| author_facet | Homa Akhavan Aghghaleh Najmeh Ranji Hadi Habibollahi |
| author_sort | Homa Akhavan Aghghaleh |
| collection | DOAJ |
| description | Background: Gastric cancer is a type of malignancy that affects the digestive system. Symptoms of gastric cancer are often hard to detect in the early stages, and become more noticeable only after cancer cells have grown inside the stomach wall and spread to other parts of the body. The genetic code of the cancer cells is located within the genome. Synonymous and non-synonymous mutations are two subgroups of SNP codes. The purpose of this study was to investigate the correlation between genetic variants and susceptibility to gastric cancer in Ardabil province.
Methods: The distribution of variants in the genomic DNA of 150 volunteers from the general population of Ardabil was determined using whole exome sequencing. Databases such as Iranome, Alfa, GnomAD, and 1000G were used to compare allele frequencies. After calculating the frequency of variants using standard methods, Pearson correlation was utilized to statistically analyze their correlation with age-standardized incidence rates (ASRs) for gastric cancer in related populations. A p-value below 0.05 was deemed statistically significant for all analyses. Statistical analysis was conducted using IBM SPSS Statistics version 25.
Results: Significant differences in 19 variants , including rs10061133, rs1050631, rs12220909, rs12983273, rs1695, rs2274223, rs2292832, rs2294008, rs2505901, rs2976391, rs33927012, rs3744037, rs3745469, rs4789936, rs4986790, rs4986791, rs6194, rs63750447, and rs6505162 were found between the general population of Ardabil and other populations. A statistically significant difference was observed and reported at the 0.05 and 0.01 levels in relation to the correlation between the desired variants.
Conclusion: Results suggest a correlation between gene variants in carcinogenesis, highlighting the need for functional studies on gene cooperation in gastric cancer development. |
| format | Article |
| id | doaj-art-a1e93ea463c644bab6599f0271154257 |
| institution | OA Journals |
| issn | 2228-7280 2228-7299 |
| language | fas |
| publishDate | 2024-10-01 |
| publisher | Ardabil University of Medical Sciences |
| record_format | Article |
| series | Journal of Ardabil University of Medical Sciences |
| spelling | doaj-art-a1e93ea463c644bab6599f02711542572025-08-20T01:58:27ZfasArdabil University of Medical SciencesJournal of Ardabil University of Medical Sciences2228-72802228-72992024-10-01243364387SNP-SNP Interactions and Gastric Cancer Susceptibility in Ardabil ProvinceHoma Akhavan Aghghaleh0Najmeh Ranji1Hadi Habibollahi2 Department of Biology, Faculty of Sciences, Rasht Branch, Islamic Azad University, Rasht, Iran. Department of Biology, Faculty of Sciences, Rasht Branch, Islamic Azad University, Rasht, Iran. Department of Biology, Faculty of Sciences, Rasht Branch, Islamic Azad University, Rasht, Iran. Background: Gastric cancer is a type of malignancy that affects the digestive system. Symptoms of gastric cancer are often hard to detect in the early stages, and become more noticeable only after cancer cells have grown inside the stomach wall and spread to other parts of the body. The genetic code of the cancer cells is located within the genome. Synonymous and non-synonymous mutations are two subgroups of SNP codes. The purpose of this study was to investigate the correlation between genetic variants and susceptibility to gastric cancer in Ardabil province. Methods: The distribution of variants in the genomic DNA of 150 volunteers from the general population of Ardabil was determined using whole exome sequencing. Databases such as Iranome, Alfa, GnomAD, and 1000G were used to compare allele frequencies. After calculating the frequency of variants using standard methods, Pearson correlation was utilized to statistically analyze their correlation with age-standardized incidence rates (ASRs) for gastric cancer in related populations. A p-value below 0.05 was deemed statistically significant for all analyses. Statistical analysis was conducted using IBM SPSS Statistics version 25. Results: Significant differences in 19 variants , including rs10061133, rs1050631, rs12220909, rs12983273, rs1695, rs2274223, rs2292832, rs2294008, rs2505901, rs2976391, rs33927012, rs3744037, rs3745469, rs4789936, rs4986790, rs4986791, rs6194, rs63750447, and rs6505162 were found between the general population of Ardabil and other populations. A statistically significant difference was observed and reported at the 0.05 and 0.01 levels in relation to the correlation between the desired variants. Conclusion: Results suggest a correlation between gene variants in carcinogenesis, highlighting the need for functional studies on gene cooperation in gastric cancer development.http://jarums.arums.ac.ir/article-1-2429-en.pdfgastric cancersnpardabil |
| spellingShingle | Homa Akhavan Aghghaleh Najmeh Ranji Hadi Habibollahi SNP-SNP Interactions and Gastric Cancer Susceptibility in Ardabil Province Journal of Ardabil University of Medical Sciences gastric cancer snp ardabil |
| title | SNP-SNP Interactions and Gastric Cancer Susceptibility in Ardabil Province |
| title_full | SNP-SNP Interactions and Gastric Cancer Susceptibility in Ardabil Province |
| title_fullStr | SNP-SNP Interactions and Gastric Cancer Susceptibility in Ardabil Province |
| title_full_unstemmed | SNP-SNP Interactions and Gastric Cancer Susceptibility in Ardabil Province |
| title_short | SNP-SNP Interactions and Gastric Cancer Susceptibility in Ardabil Province |
| title_sort | snp snp interactions and gastric cancer susceptibility in ardabil province |
| topic | gastric cancer snp ardabil |
| url | http://jarums.arums.ac.ir/article-1-2429-en.pdf |
| work_keys_str_mv | AT homaakhavanaghghaleh snpsnpinteractionsandgastriccancersusceptibilityinardabilprovince AT najmehranji snpsnpinteractionsandgastriccancersusceptibilityinardabilprovince AT hadihabibollahi snpsnpinteractionsandgastriccancersusceptibilityinardabilprovince |