Immune inflammation and metabolic interactions in the pathogenesis of diabetic nephropathy

Immune inflammation and metabolic interactions in the pathogenesis of diabetic nephropathy

Diabetic nephropathy (DN) is a significant microvascular complication of diabetes, substantially contributing to the global prevalence of end-stage renal disease. The pathogenesis of DN is multifactorial, involving both immune-inflammatory responses and metabolic dysregulation. Hyperglycemia, a hall...

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Bibliographic Details
Main Authors: Guangjian Hou, Youzi Dong, Yuehua Jiang, Wenbo Zhao, Le Zhou, Shengnan Cao, Wei Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Endocrinology
Subjects:
diabetic nephropathy
immune-inflammatory response
metabolic signaling pathways
kidney damage
immune cells
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1602594/full
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