Hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Case report
The frequency of myopathy in hypothyroidism ranges from 30 to 80%. The major symptoms related are weakness, muscular cramps and myalgia. The pseudohyperthrophic form is called Hoffman's syndrome. The electrophysiological study reveals myopathy, neuropathy or mixed pattern. Laboratorial investig...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Thieme Revinter Publicações
2003-09-01
|
| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2003000500027&tlng=en |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850244129991163904 |
|---|---|
| author | Luiz Felipe Rocha Vasconcellos Maria Claudia Peixoto Tatiana Nunes de Oliveira Glória Penque Ana Claudia Celestino Leite |
| author_facet | Luiz Felipe Rocha Vasconcellos Maria Claudia Peixoto Tatiana Nunes de Oliveira Glória Penque Ana Claudia Celestino Leite |
| author_sort | Luiz Felipe Rocha Vasconcellos |
| collection | DOAJ |
| description | The frequency of myopathy in hypothyroidism ranges from 30 to 80%. The major symptoms related are weakness, muscular cramps and myalgia. The pseudohyperthrophic form is called Hoffman's syndrome. The electrophysiological study reveals myopathy, neuropathy or mixed pattern. Laboratorial investigation generally shows increased levels of muscle enzymes and low serum thyroid hormones, with thyrotrophic-stimulating hormone (TSH) elevated. The treatment consists in hormone replacement and the prognosis is good in most of the cases. We report an adult male who developed muscular cramps, myalgia, weakness, pseudohyperthrophy, associated with facial edema and alteration of his voice. The muscle enzymes were increased and T4 was undetectable with a raised level of TSH. The myopathy was the initial manifestation of hypothyroidism in this case. |
| format | Article |
| id | doaj-art-a1e13ce0b51e4ea6be58123bf1c18cc1 |
| institution | OA Journals |
| issn | 1678-4227 |
| language | English |
| publishDate | 2003-09-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-a1e13ce0b51e4ea6be58123bf1c18cc12025-08-20T01:59:48ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272003-09-01613B85185410.1590/S0004-282X2003000500027Hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Case reportLuiz Felipe Rocha Vasconcellos0Maria Claudia Peixoto1Tatiana Nunes de Oliveira2Glória Penque3Ana Claudia Celestino Leite4University Hospital Clementino Fraga FilhoUniversity Hospital Clementino Fraga FilhoUniversity Hospital Clementino Fraga FilhoINDCUniversity Hospital Clementino Fraga FilhoThe frequency of myopathy in hypothyroidism ranges from 30 to 80%. The major symptoms related are weakness, muscular cramps and myalgia. The pseudohyperthrophic form is called Hoffman's syndrome. The electrophysiological study reveals myopathy, neuropathy or mixed pattern. Laboratorial investigation generally shows increased levels of muscle enzymes and low serum thyroid hormones, with thyrotrophic-stimulating hormone (TSH) elevated. The treatment consists in hormone replacement and the prognosis is good in most of the cases. We report an adult male who developed muscular cramps, myalgia, weakness, pseudohyperthrophy, associated with facial edema and alteration of his voice. The muscle enzymes were increased and T4 was undetectable with a raised level of TSH. The myopathy was the initial manifestation of hypothyroidism in this case.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2003000500027&tlng=enmyopathyhypothyroidismpseudohypertrophy |
| spellingShingle | Luiz Felipe Rocha Vasconcellos Maria Claudia Peixoto Tatiana Nunes de Oliveira Glória Penque Ana Claudia Celestino Leite Hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Case report Arquivos de Neuro-Psiquiatria myopathy hypothyroidism pseudohypertrophy |
| title | Hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Case report |
| title_full | Hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Case report |
| title_fullStr | Hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Case report |
| title_full_unstemmed | Hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Case report |
| title_short | Hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Case report |
| title_sort | hoffman s syndrome pseudohypertrophic myopathy as initial manifestation of hypothyroidism case report |
| topic | myopathy hypothyroidism pseudohypertrophy |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2003000500027&tlng=en |
| work_keys_str_mv | AT luizfeliperochavasconcellos hoffmanssyndromepseudohypertrophicmyopathyasinitialmanifestationofhypothyroidismcasereport AT mariaclaudiapeixoto hoffmanssyndromepseudohypertrophicmyopathyasinitialmanifestationofhypothyroidismcasereport AT tatiananunesdeoliveira hoffmanssyndromepseudohypertrophicmyopathyasinitialmanifestationofhypothyroidismcasereport AT gloriapenque hoffmanssyndromepseudohypertrophicmyopathyasinitialmanifestationofhypothyroidismcasereport AT anaclaudiacelestinoleite hoffmanssyndromepseudohypertrophicmyopathyasinitialmanifestationofhypothyroidismcasereport |