Clinical impact of air pollution on SPECT myocardial perfusion imaging
Background: Air pollution contributes to cardiovascular morbimortality. Air pollution effects on cardiovascular function assessed from non-invasive and invasive imaging have been reported but never on myocardial perfusion. This study aimed to characterize relations of air pollution exposure to myoca...
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Elsevier
2025-04-01
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| Series: | Environment International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412025001576 |
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| author | Océane Bouchot Stephan Gabet Loïc Djaileb Aurélia Robin Nicolas De Leiris Julie Roux Laurent Riou Gerald Vanzetto Daniel Fagret Catherine Ghezzi Rémy Slama Gilles Barone-Rochette |
| author_facet | Océane Bouchot Stephan Gabet Loïc Djaileb Aurélia Robin Nicolas De Leiris Julie Roux Laurent Riou Gerald Vanzetto Daniel Fagret Catherine Ghezzi Rémy Slama Gilles Barone-Rochette |
| author_sort | Océane Bouchot |
| collection | DOAJ |
| description | Background: Air pollution contributes to cardiovascular morbimortality. Air pollution effects on cardiovascular function assessed from non-invasive and invasive imaging have been reported but never on myocardial perfusion. This study aimed to characterize relations of air pollution exposure to myocardial perfusion imaging (MPI). Methods: Patients referred to SPECT (single-photon emission computed tomography) MPI were prospectively enrolled between 2017 and 2020. Myocardial ischemia was assessed from the SPECT. Moderate-to-severe ischemia was defined as a > 10 % ischemic myocardium. Exposures to particulate matter (PM2.5 and PM10) and NO2 at the home address were characterized via a 10-meter resolution air pollutant-dispersion model and air quality monitoring system data. Associations of exposures with scintigraphy parameters were assessed through multivariable regressions, and potential modifying effects by sex and BMI were investigated. Results: A total of 1,585 participants were prospectively included (mean age 67.7 ± 11.6 years, 63.3 % male); 148 (9.3 %) patients presented a moderate-to-severe ischemia. In multivariate analysis, the odds of moderate-to-severe ischemia was increased, with adjusted odds-ratio (ORa) of 1.39 [95 % confidence interval (95 % CI): 1.07–1.80; p = 0.013], 1.33 (95 % CI: 1.01–1.75; p = 0.042), and 1.22 (95 % CI: 0.96–1.57; p = 0.10) for each increase of one Interquartile Range (IQR) in PM2.5, PM10 and NO2 exposure, respectively (IQR equal to 3.3, 4.3 and 10.0 µg/m3, respectively). With further adjustment for cardiometabolic diseases and symptoms, only the association with PM2.5 remained statistically significant: ORa 1.34 (95 % CI: 1.03–1.75, p = 0.031) for each one-IQR increase. Associations with PM10 and PM2.5 tended to be stronger in women (interaction p-value equal to 0.11 and 0.077, respectively). Conclusion: We provide new insights into a mechanism by which particulate air pollution may influence cardiovascular risk. Exposure to PM was associated with moderate-to-severe ischemia, particularly in women. |
| format | Article |
| id | doaj-art-a1df12e3150c49d69e34ae4ec6c61017 |
| institution | DOAJ |
| issn | 0160-4120 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
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| series | Environment International |
| spelling | doaj-art-a1df12e3150c49d69e34ae4ec6c610172025-08-20T03:14:54ZengElsevierEnvironment International0160-41202025-04-0119810940610.1016/j.envint.2025.109406Clinical impact of air pollution on SPECT myocardial perfusion imagingOcéane Bouchot0Stephan Gabet1Loïc Djaileb2Aurélia Robin3Nicolas De Leiris4Julie Roux5Laurent Riou6Gerald Vanzetto7Daniel Fagret8Catherine Ghezzi9Rémy Slama10Gilles Barone-Rochette11Department of Cardiology, Annecy Genevois Hospital, FranceUniv. Grenoble-Alpes, Inserm, CNRS, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, IAB, 38000 Grenoble, France; Univ. Lille, CHU Lille, Institut Pasteur de Lille, ULR 4483-IMPacts de l’Environnement Chimique sur la Santé (IMPECS), F-59000 Lille, FranceUniv. Grenoble Alpes, INSERM, CHU Grenoble Alpes, LRB, 38000 Grenoble, France; Department of Nuclear Medicine, University Hospital, Grenoble Alpes, FranceUniv. Grenoble Alpes, INSERM, CHU Grenoble Alpes, LRB, 38000 Grenoble, FranceUniv. Grenoble Alpes, INSERM, CHU Grenoble Alpes, LRB, 38000 Grenoble, France; Department of Nuclear Medicine, University Hospital, Grenoble Alpes, FranceUniv. Grenoble Alpes, INSERM, CHU Grenoble Alpes, LRB, 38000 Grenoble, France; Department of Nuclear Medicine, University Hospital, Grenoble Alpes, FranceUniv. Grenoble Alpes, INSERM, CHU Grenoble Alpes, LRB, 38000 Grenoble, France; Department of Nuclear Medicine, University Hospital, Grenoble Alpes, FranceDepartment of Nuclear Medicine, University Hospital, Grenoble Alpes, France; Department of Cardiology, University Hospital, Grenoble Alpes, France; French Alliance Clinical Trial, French Clinical Research Infrastructure Network, 75018 Paris, FranceUniv. Grenoble Alpes, INSERM, CHU Grenoble Alpes, LRB, 38000 Grenoble, France; Department of Nuclear Medicine, University Hospital, Grenoble Alpes, FranceUniv. Grenoble Alpes, INSERM, CHU Grenoble Alpes, LRB, 38000 Grenoble, France; Department of Nuclear Medicine, University Hospital, Grenoble Alpes, FranceUniv. Grenoble-Alpes, Inserm, CNRS, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, IAB, 38000 Grenoble, FranceUniv. Grenoble Alpes, INSERM, CHU Grenoble Alpes, LRB, 38000 Grenoble, France; Department of Cardiology, University Hospital, Grenoble Alpes, France; French Alliance Clinical Trial, French Clinical Research Infrastructure Network, 75018 Paris, France; Corresponding author at: Clinique Universitaire de Cardiologie / Pôle Thorax et Vx, CHU de Grenoble, 38043 Grenoble cedex 09, France.Background: Air pollution contributes to cardiovascular morbimortality. Air pollution effects on cardiovascular function assessed from non-invasive and invasive imaging have been reported but never on myocardial perfusion. This study aimed to characterize relations of air pollution exposure to myocardial perfusion imaging (MPI). Methods: Patients referred to SPECT (single-photon emission computed tomography) MPI were prospectively enrolled between 2017 and 2020. Myocardial ischemia was assessed from the SPECT. Moderate-to-severe ischemia was defined as a > 10 % ischemic myocardium. Exposures to particulate matter (PM2.5 and PM10) and NO2 at the home address were characterized via a 10-meter resolution air pollutant-dispersion model and air quality monitoring system data. Associations of exposures with scintigraphy parameters were assessed through multivariable regressions, and potential modifying effects by sex and BMI were investigated. Results: A total of 1,585 participants were prospectively included (mean age 67.7 ± 11.6 years, 63.3 % male); 148 (9.3 %) patients presented a moderate-to-severe ischemia. In multivariate analysis, the odds of moderate-to-severe ischemia was increased, with adjusted odds-ratio (ORa) of 1.39 [95 % confidence interval (95 % CI): 1.07–1.80; p = 0.013], 1.33 (95 % CI: 1.01–1.75; p = 0.042), and 1.22 (95 % CI: 0.96–1.57; p = 0.10) for each increase of one Interquartile Range (IQR) in PM2.5, PM10 and NO2 exposure, respectively (IQR equal to 3.3, 4.3 and 10.0 µg/m3, respectively). With further adjustment for cardiometabolic diseases and symptoms, only the association with PM2.5 remained statistically significant: ORa 1.34 (95 % CI: 1.03–1.75, p = 0.031) for each one-IQR increase. Associations with PM10 and PM2.5 tended to be stronger in women (interaction p-value equal to 0.11 and 0.077, respectively). Conclusion: We provide new insights into a mechanism by which particulate air pollution may influence cardiovascular risk. Exposure to PM was associated with moderate-to-severe ischemia, particularly in women.http://www.sciencedirect.com/science/article/pii/S0160412025001576Air pollutionSingle-photon emission computed tomographyMyocardial perfusion imagingMyocardial ischemia |
| spellingShingle | Océane Bouchot Stephan Gabet Loïc Djaileb Aurélia Robin Nicolas De Leiris Julie Roux Laurent Riou Gerald Vanzetto Daniel Fagret Catherine Ghezzi Rémy Slama Gilles Barone-Rochette Clinical impact of air pollution on SPECT myocardial perfusion imaging Environment International Air pollution Single-photon emission computed tomography Myocardial perfusion imaging Myocardial ischemia |
| title | Clinical impact of air pollution on SPECT myocardial perfusion imaging |
| title_full | Clinical impact of air pollution on SPECT myocardial perfusion imaging |
| title_fullStr | Clinical impact of air pollution on SPECT myocardial perfusion imaging |
| title_full_unstemmed | Clinical impact of air pollution on SPECT myocardial perfusion imaging |
| title_short | Clinical impact of air pollution on SPECT myocardial perfusion imaging |
| title_sort | clinical impact of air pollution on spect myocardial perfusion imaging |
| topic | Air pollution Single-photon emission computed tomography Myocardial perfusion imaging Myocardial ischemia |
| url | http://www.sciencedirect.com/science/article/pii/S0160412025001576 |
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