Synthesis of 2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)acetamide Based Thiazolidinone Derivatives as Potent Antibacterial and Antifungal Agents
Twelve compounds belonging to series 2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)-N-[4-oxo-2-(substituted)phenyl-1,3-thiazolidin-3-yl]acetamide (5a-l) were synthesized. These compounds were evaluated for their in-vitro antibacterial against E. coli, S. aureus, K. pneumoniae, P. aeruginosa & antifungal...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2012/857514 |
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| author | Shiv Kumar Nitin Kumar Sushma Drabu Suroor Ahmed Khan Ozair Alam Manav Malhotra Md. Akram Minhaj |
| author_facet | Shiv Kumar Nitin Kumar Sushma Drabu Suroor Ahmed Khan Ozair Alam Manav Malhotra Md. Akram Minhaj |
| author_sort | Shiv Kumar |
| collection | DOAJ |
| description | Twelve compounds belonging to series 2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)-N-[4-oxo-2-(substituted)phenyl-1,3-thiazolidin-3-yl]acetamide (5a-l) were synthesized. These compounds were evaluated for their in-vitro antibacterial against E. coli, S. aureus, K. pneumoniae, P. aeruginosa & antifungal activity against C. albicans, A. niger & A. flavus by cup-plate method. Structures of all the newly synthesized compounds were confirmed by elemental analysis, 1H-NMR & FT-IR spectral data interpretation. Compounds 5d & 5h having p-nitrophenyl & p-trifluoromethylphenyl group respectively on 2-position of thiazolidinone ring attached to N-atom of acetamido group on 1-position of 3-methyl-1H-quinoxaline-2-one, were found to be active against all the bacterial & fungal strains under investigation, while compound 5l having p-chlorophenyl on 2-position of thiazolidinone nucleus was reported as least active compound against all bacterial & fungal strain under investigation. |
| format | Article |
| id | doaj-art-a1dcb7de21784a99b02eda34ebf77b5a |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-a1dcb7de21784a99b02eda34ebf77b5a2025-02-03T06:00:28ZengWileyE-Journal of Chemistry0973-49452090-98102012-01-01942155216510.1155/2012/857514Synthesis of 2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)acetamide Based Thiazolidinone Derivatives as Potent Antibacterial and Antifungal AgentsShiv Kumar0Nitin Kumar1Sushma Drabu2Suroor Ahmed Khan3Ozair Alam4Manav Malhotra5Md. Akram Minhaj6Division of Pharmaceutical Chemistry, Department of Pharmacy, IEC College of Engineering & Technology, Knowledge Park-I, Greater Noida-201306, IndiaDepartment of Pharmaceutical Technology, Meerut Institute of Engineering & Technology, Meerut-250005, IndiaMaharaja Surajmal Institute of Pharmacy, Janak Puri, New Delhi-110058, IndiaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi-110062, IndiaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi-110062, IndiaDepartment of Pharmaceutical Chemistry, ISF College of Pharmacy, Ferozpur Road, Moga-142001, IndiaDivision of Pharmaceutical Chemistry, Department of Pharmacy, IEC College of Engineering & Technology, Knowledge Park-I, Greater Noida-201306, IndiaTwelve compounds belonging to series 2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)-N-[4-oxo-2-(substituted)phenyl-1,3-thiazolidin-3-yl]acetamide (5a-l) were synthesized. These compounds were evaluated for their in-vitro antibacterial against E. coli, S. aureus, K. pneumoniae, P. aeruginosa & antifungal activity against C. albicans, A. niger & A. flavus by cup-plate method. Structures of all the newly synthesized compounds were confirmed by elemental analysis, 1H-NMR & FT-IR spectral data interpretation. Compounds 5d & 5h having p-nitrophenyl & p-trifluoromethylphenyl group respectively on 2-position of thiazolidinone ring attached to N-atom of acetamido group on 1-position of 3-methyl-1H-quinoxaline-2-one, were found to be active against all the bacterial & fungal strains under investigation, while compound 5l having p-chlorophenyl on 2-position of thiazolidinone nucleus was reported as least active compound against all bacterial & fungal strain under investigation.http://dx.doi.org/10.1155/2012/857514 |
| spellingShingle | Shiv Kumar Nitin Kumar Sushma Drabu Suroor Ahmed Khan Ozair Alam Manav Malhotra Md. Akram Minhaj Synthesis of 2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)acetamide Based Thiazolidinone Derivatives as Potent Antibacterial and Antifungal Agents E-Journal of Chemistry |
| title | Synthesis of 2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)acetamide Based Thiazolidinone Derivatives as Potent Antibacterial and Antifungal Agents |
| title_full | Synthesis of 2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)acetamide Based Thiazolidinone Derivatives as Potent Antibacterial and Antifungal Agents |
| title_fullStr | Synthesis of 2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)acetamide Based Thiazolidinone Derivatives as Potent Antibacterial and Antifungal Agents |
| title_full_unstemmed | Synthesis of 2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)acetamide Based Thiazolidinone Derivatives as Potent Antibacterial and Antifungal Agents |
| title_short | Synthesis of 2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)acetamide Based Thiazolidinone Derivatives as Potent Antibacterial and Antifungal Agents |
| title_sort | synthesis of 2 3 methyl 2 oxoquinoxalin 1 2h yl acetamide based thiazolidinone derivatives as potent antibacterial and antifungal agents |
| url | http://dx.doi.org/10.1155/2012/857514 |
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