Gut Microbiome as a Potential Marker of Hematologic Recovery Following Induction Therapy in Acute Myeloid Leukemia Patients
ABSTRACT Background The management of acute myeloid leukemia (AML) is hindered by treatment‐related toxicities and complications, particularly cytopenia, which remains a leading cause of mortality. Given the pivotal role of the gut microbiota (GM) in hemopoiesis and immune regulation, we investigate...
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| Format: | Article |
| Language: | English |
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Wiley
2025-02-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.70501 |
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| author | Valentina Salvestrini Gabriele Conti Federica D'Amico Gianluca Cristiano Marco Candela Michele Cavo Silvia Turroni Antonio Curti |
| author_facet | Valentina Salvestrini Gabriele Conti Federica D'Amico Gianluca Cristiano Marco Candela Michele Cavo Silvia Turroni Antonio Curti |
| author_sort | Valentina Salvestrini |
| collection | DOAJ |
| description | ABSTRACT Background The management of acute myeloid leukemia (AML) is hindered by treatment‐related toxicities and complications, particularly cytopenia, which remains a leading cause of mortality. Given the pivotal role of the gut microbiota (GM) in hemopoiesis and immune regulation, we investigated its impact on hematologic recovery during AML induction therapy. Methods We profiled the GM of 27 newly diagnosed adult AML patients using 16S rRNA amplicon sequencing and correlated it with key clinical parameters before and after induction therapy. Results Our investigation revealed intriguing associations between the GM composition and crucial recovery indicators, including platelet, lymphocyte, and neutrophil counts, and identified early GM signatures predictive of improved hematologic recovery. Remarkably, patients demonstrating superior recovery had higher alpha diversity and enrichment in health‐associated taxa belonging to the genera Faecalibacterium, Ruminococcus, Blautia, and Butyricimonas at diagnosis. Conclusions Despite certain study limitations, our findings suggest that evaluating GM features could serve as a potential marker for hematologic recovery. This preliminary work opens avenues for personalized risk assessment and interventions, possibly involving GM modulation tools, to optimize recovery in AML patients undergoing induction therapy and potentially enhancing overall outcomes in individuals with hematologic diseases. |
| format | Article |
| id | doaj-art-a1dae34e81fc424ba22b88be2188cd8b |
| institution | Kabale University |
| issn | 2045-7634 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-a1dae34e81fc424ba22b88be2188cd8b2025-08-20T03:27:57ZengWileyCancer Medicine2045-76342025-02-01143n/an/a10.1002/cam4.70501Gut Microbiome as a Potential Marker of Hematologic Recovery Following Induction Therapy in Acute Myeloid Leukemia PatientsValentina Salvestrini0Gabriele Conti1Federica D'Amico2Gianluca Cristiano3Marco Candela4Michele Cavo5Silvia Turroni6Antonio Curti7Istituto di Ematologia "Seràgnoli" IRCCS Azienda Ospedaliero‐Universitaria di Bologna Bologna ItalyHuman Microbiomics Unit, Department of Medical and Surgical Sciences University of Bologna Bologna ItalyUnit of Microbiome Science and Biotechnology, Department of Pharmacy and Biotechnology University of Bologna Bologna ItalyOncology and Haematology Research Area, Department of Medical and Surgical Sciences University of Bologna Bologna ItalyUnit of Microbiome Science and Biotechnology, Department of Pharmacy and Biotechnology University of Bologna Bologna ItalyIstituto di Ematologia "Seràgnoli" IRCCS Azienda Ospedaliero‐Universitaria di Bologna Bologna ItalyUnit of Microbiome Science and Biotechnology, Department of Pharmacy and Biotechnology University of Bologna Bologna ItalyIstituto di Ematologia "Seràgnoli" IRCCS Azienda Ospedaliero‐Universitaria di Bologna Bologna ItalyABSTRACT Background The management of acute myeloid leukemia (AML) is hindered by treatment‐related toxicities and complications, particularly cytopenia, which remains a leading cause of mortality. Given the pivotal role of the gut microbiota (GM) in hemopoiesis and immune regulation, we investigated its impact on hematologic recovery during AML induction therapy. Methods We profiled the GM of 27 newly diagnosed adult AML patients using 16S rRNA amplicon sequencing and correlated it with key clinical parameters before and after induction therapy. Results Our investigation revealed intriguing associations between the GM composition and crucial recovery indicators, including platelet, lymphocyte, and neutrophil counts, and identified early GM signatures predictive of improved hematologic recovery. Remarkably, patients demonstrating superior recovery had higher alpha diversity and enrichment in health‐associated taxa belonging to the genera Faecalibacterium, Ruminococcus, Blautia, and Butyricimonas at diagnosis. Conclusions Despite certain study limitations, our findings suggest that evaluating GM features could serve as a potential marker for hematologic recovery. This preliminary work opens avenues for personalized risk assessment and interventions, possibly involving GM modulation tools, to optimize recovery in AML patients undergoing induction therapy and potentially enhancing overall outcomes in individuals with hematologic diseases.https://doi.org/10.1002/cam4.70501acute myeloid leukemiagut microbiomehematological recoveryinduction therapy |
| spellingShingle | Valentina Salvestrini Gabriele Conti Federica D'Amico Gianluca Cristiano Marco Candela Michele Cavo Silvia Turroni Antonio Curti Gut Microbiome as a Potential Marker of Hematologic Recovery Following Induction Therapy in Acute Myeloid Leukemia Patients Cancer Medicine acute myeloid leukemia gut microbiome hematological recovery induction therapy |
| title | Gut Microbiome as a Potential Marker of Hematologic Recovery Following Induction Therapy in Acute Myeloid Leukemia Patients |
| title_full | Gut Microbiome as a Potential Marker of Hematologic Recovery Following Induction Therapy in Acute Myeloid Leukemia Patients |
| title_fullStr | Gut Microbiome as a Potential Marker of Hematologic Recovery Following Induction Therapy in Acute Myeloid Leukemia Patients |
| title_full_unstemmed | Gut Microbiome as a Potential Marker of Hematologic Recovery Following Induction Therapy in Acute Myeloid Leukemia Patients |
| title_short | Gut Microbiome as a Potential Marker of Hematologic Recovery Following Induction Therapy in Acute Myeloid Leukemia Patients |
| title_sort | gut microbiome as a potential marker of hematologic recovery following induction therapy in acute myeloid leukemia patients |
| topic | acute myeloid leukemia gut microbiome hematological recovery induction therapy |
| url | https://doi.org/10.1002/cam4.70501 |
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