Evaluating the impact of polycythemia vera on retinal and optic nerve head microvascularity: An OCTA study
Purpose: This study aims to assess the impact of polycythemia vera (PV) on retinal and optic nerve head (ONH) vessel density (VD) parameters, macular ganglion cell complex (mGCC) thickness, and retinal nerve fiber layer (RNFL) thickness compared to healthy controls. Methods: Forty eyes of 20 patient...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-11-01
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| Series: | Indian Journal of Ophthalmology |
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| Online Access: | https://journals.lww.com/10.4103/IJO.IJO_1322_24 |
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| author | Meryem Feyza Cicek Turker Oba Abdullah Ağın Mesut Ayer Feyza Onder |
| author_facet | Meryem Feyza Cicek Turker Oba Abdullah Ağın Mesut Ayer Feyza Onder |
| author_sort | Meryem Feyza Cicek |
| collection | DOAJ |
| description | Purpose:
This study aims to assess the impact of polycythemia vera (PV) on retinal and optic nerve head (ONH) vessel density (VD) parameters, macular ganglion cell complex (mGCC) thickness, and retinal nerve fiber layer (RNFL) thickness compared to healthy controls.
Methods:
Forty eyes of 20 patients with PV and 40 eyes of 20 age-gender-matched healthy controls underwent comprehensive ophthalmologic assessments and optic coherence tomography angiography (OCTA). RNFL and macular GCC measurements were obtained simultaneously with vascular parameters by AngioVue OCTA using the single-scan protocol. Peripapillary VD was examined across eight sectors, whereas parameters including RNFL, GCC, and macular VD were analyzed in four quadrants.
Results:
Patients with PV exhibited significant reductions in the average RNFL thickness (P = 0.014) and RNFL thickness in superior (P < 0.001) and inferior (P = 0.003) quadrants compared to controls. Additionally, mGCC thickness in all quadrants significantly reduced in the PV group (P < 0.001). ONH VD parameters, including whole-image VD (P < 0.001) and peripapillary VD (P < 0.001), were significantly reduced in patients with PV. Similarly, macular VD parameters were significantly lower in the PV group (P < 0.001).
Conclusion:
This study highlights substantial vascular and structural alterations in the retina and ONH of patients with PV compared to healthy controls. These changes likely stem from microvascular dysfunction associated with PV. These findings suggest further research to understand the underlying mechanisms and develop targeted therapeutic strategies for managing ocular complications in patients with PV. |
| format | Article |
| id | doaj-art-a1d551dfd7c54de081ad786da46dd960 |
| institution | OA Journals |
| issn | 0301-4738 1998-3689 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj-art-a1d551dfd7c54de081ad786da46dd9602025-08-20T02:18:03ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892024-11-0172Suppl 5S863S86910.4103/IJO.IJO_1322_24Evaluating the impact of polycythemia vera on retinal and optic nerve head microvascularity: An OCTA studyMeryem Feyza CicekTurker ObaAbdullah AğınMesut AyerFeyza OnderPurpose: This study aims to assess the impact of polycythemia vera (PV) on retinal and optic nerve head (ONH) vessel density (VD) parameters, macular ganglion cell complex (mGCC) thickness, and retinal nerve fiber layer (RNFL) thickness compared to healthy controls. Methods: Forty eyes of 20 patients with PV and 40 eyes of 20 age-gender-matched healthy controls underwent comprehensive ophthalmologic assessments and optic coherence tomography angiography (OCTA). RNFL and macular GCC measurements were obtained simultaneously with vascular parameters by AngioVue OCTA using the single-scan protocol. Peripapillary VD was examined across eight sectors, whereas parameters including RNFL, GCC, and macular VD were analyzed in four quadrants. Results: Patients with PV exhibited significant reductions in the average RNFL thickness (P = 0.014) and RNFL thickness in superior (P < 0.001) and inferior (P = 0.003) quadrants compared to controls. Additionally, mGCC thickness in all quadrants significantly reduced in the PV group (P < 0.001). ONH VD parameters, including whole-image VD (P < 0.001) and peripapillary VD (P < 0.001), were significantly reduced in patients with PV. Similarly, macular VD parameters were significantly lower in the PV group (P < 0.001). Conclusion: This study highlights substantial vascular and structural alterations in the retina and ONH of patients with PV compared to healthy controls. These changes likely stem from microvascular dysfunction associated with PV. These findings suggest further research to understand the underlying mechanisms and develop targeted therapeutic strategies for managing ocular complications in patients with PV.https://journals.lww.com/10.4103/IJO.IJO_1322_24octaoptic nerve head perfusionpolycythemia veraretinal vascularity |
| spellingShingle | Meryem Feyza Cicek Turker Oba Abdullah Ağın Mesut Ayer Feyza Onder Evaluating the impact of polycythemia vera on retinal and optic nerve head microvascularity: An OCTA study Indian Journal of Ophthalmology octa optic nerve head perfusion polycythemia vera retinal vascularity |
| title | Evaluating the impact of polycythemia vera on retinal and optic nerve head microvascularity: An OCTA study |
| title_full | Evaluating the impact of polycythemia vera on retinal and optic nerve head microvascularity: An OCTA study |
| title_fullStr | Evaluating the impact of polycythemia vera on retinal and optic nerve head microvascularity: An OCTA study |
| title_full_unstemmed | Evaluating the impact of polycythemia vera on retinal and optic nerve head microvascularity: An OCTA study |
| title_short | Evaluating the impact of polycythemia vera on retinal and optic nerve head microvascularity: An OCTA study |
| title_sort | evaluating the impact of polycythemia vera on retinal and optic nerve head microvascularity an octa study |
| topic | octa optic nerve head perfusion polycythemia vera retinal vascularity |
| url | https://journals.lww.com/10.4103/IJO.IJO_1322_24 |
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