Biophysical Insights into Cancer Transformation and Treatment
Biological systems are hierarchically self-organized complex structures characterized by nonlinear interactions. Biochemical energy is transformed into work of physical forces required for various biological functions. We postulate that energy transduction depends on endogenous electrodynamic fields...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/195028 |
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| _version_ | 1832547592734507008 |
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| author | Jiří Pokorný Alberto Foletti Jitka Kobilková Anna Jandová Jan Vrba Jan Vrba Martina Nedbalová Aleš Čoček Andrea Danani Jack A. Tuszyński |
| author_facet | Jiří Pokorný Alberto Foletti Jitka Kobilková Anna Jandová Jan Vrba Jan Vrba Martina Nedbalová Aleš Čoček Andrea Danani Jack A. Tuszyński |
| author_sort | Jiří Pokorný |
| collection | DOAJ |
| description | Biological systems are hierarchically self-organized complex structures characterized by nonlinear interactions. Biochemical energy is transformed into work of physical forces required for various biological functions. We postulate that energy transduction depends on endogenous electrodynamic fields generated by microtubules. Microtubules and mitochondria colocalize in cells with microtubules providing tracks for mitochondrial movement. Besides energy transformation, mitochondria form a spatially distributed proton charge layer and a resultant strong static electric field, which causes water ordering in the surrounding cytosol. These effects create conditions for generation of coherent electrodynamic field. The metabolic energy transduction pathways are strongly affected in cancers. Mitochondrial dysfunction in cancer cells (Warburg effect) or in fibroblasts associated with cancer cells (reverse Warburg effect) results in decreased or increased power of the generated electromagnetic field, respectively, and shifted and rebuilt frequency spectra. Disturbed electrodynamic interaction forces between cancer and healthy cells may favor local invasion and metastasis. A therapeutic strategy of targeting dysfunctional mitochondria for restoration of their physiological functions makes it possible to switch on the natural apoptotic pathway blocked in cancer transformed cells. Experience with dichloroacetate in cancer treatment and reestablishment of the healthy state may help in the development of novel effective drugs aimed at the mitochondrial function. |
| format | Article |
| id | doaj-art-a1d3f934e19c48a7a2b703f3df4fc09f |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-a1d3f934e19c48a7a2b703f3df4fc09f2025-02-03T06:44:18ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/195028195028Biophysical Insights into Cancer Transformation and TreatmentJiří Pokorný0Alberto Foletti1Jitka Kobilková2Anna Jandová3Jan Vrba4Jan Vrba5Martina Nedbalová6Aleš Čoček7Andrea Danani8Jack A. Tuszyński9Institute of Photonics and Electronics, Academy of Sciences of the Czech Republic, AS CR, Chaberská 57, 182 51 Prague 8-Kobylisy, Czech RepublicInstitute of Translational Pharmacology, National Research Council-CNR, Via Fosso del Cavaliere 100, 00133 Rome, Italy1st Faculty of Medicine, Charles University in Prague, Department of Obstetrics and Gynaecology, Apolinářská 18, 128 00 Prague 2, Czech RepublicInstitute of Photonics and Electronics, Academy of Sciences of the Czech Republic, AS CR, Chaberská 57, 182 51 Prague 8-Kobylisy, Czech RepublicFaculty of Electrical Engineering, Czech Technical University in Prague, Technická 2, 166 27 Prague 6, Czech RepublicFaculty of Biomedical Engineering, Czech Technical University in Kladno, Sitná Square 3105, 272 01 Kladno, Czech Republic1st Faculty of Medicine, Charles University in Prague, Institute of Physiology, Albertov 5, 128 00 Prague 2, Czech Republic3rd Faculty of Medicine, Charles University in Prague, Department of Otorhinolaryngology, Ruská 87, 100 00 Prague 10, Czech RepublicUniversity of Applied Sciences of Southern Switzerland-SUPSI, Department of Innovative Technologies, Galleria 2, 6928 Manno, SwitzerlandDepartment of Physics, University of Alberta, Edmonton, AB, T6G 2J7, CanadaBiological systems are hierarchically self-organized complex structures characterized by nonlinear interactions. Biochemical energy is transformed into work of physical forces required for various biological functions. We postulate that energy transduction depends on endogenous electrodynamic fields generated by microtubules. Microtubules and mitochondria colocalize in cells with microtubules providing tracks for mitochondrial movement. Besides energy transformation, mitochondria form a spatially distributed proton charge layer and a resultant strong static electric field, which causes water ordering in the surrounding cytosol. These effects create conditions for generation of coherent electrodynamic field. The metabolic energy transduction pathways are strongly affected in cancers. Mitochondrial dysfunction in cancer cells (Warburg effect) or in fibroblasts associated with cancer cells (reverse Warburg effect) results in decreased or increased power of the generated electromagnetic field, respectively, and shifted and rebuilt frequency spectra. Disturbed electrodynamic interaction forces between cancer and healthy cells may favor local invasion and metastasis. A therapeutic strategy of targeting dysfunctional mitochondria for restoration of their physiological functions makes it possible to switch on the natural apoptotic pathway blocked in cancer transformed cells. Experience with dichloroacetate in cancer treatment and reestablishment of the healthy state may help in the development of novel effective drugs aimed at the mitochondrial function.http://dx.doi.org/10.1155/2013/195028 |
| spellingShingle | Jiří Pokorný Alberto Foletti Jitka Kobilková Anna Jandová Jan Vrba Jan Vrba Martina Nedbalová Aleš Čoček Andrea Danani Jack A. Tuszyński Biophysical Insights into Cancer Transformation and Treatment The Scientific World Journal |
| title | Biophysical Insights into Cancer Transformation and Treatment |
| title_full | Biophysical Insights into Cancer Transformation and Treatment |
| title_fullStr | Biophysical Insights into Cancer Transformation and Treatment |
| title_full_unstemmed | Biophysical Insights into Cancer Transformation and Treatment |
| title_short | Biophysical Insights into Cancer Transformation and Treatment |
| title_sort | biophysical insights into cancer transformation and treatment |
| url | http://dx.doi.org/10.1155/2013/195028 |
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