Periodontal Ligament Stem Cells: Current Status, Concerns, and Future Prospects
Periodontal ligament stem cells (PDLSCs), which reside in the perivascular space of the periodontium, possess characteristics of mesenchymal stem cells and are a promising tool for periodontal regeneration. Recently, great progress has been made in PDLSC transplantation. Investigators are attempting...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2015/972313 |
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| _version_ | 1850169450858283008 |
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| author | Wenjun Zhu Min Liang |
| author_facet | Wenjun Zhu Min Liang |
| author_sort | Wenjun Zhu |
| collection | DOAJ |
| description | Periodontal ligament stem cells (PDLSCs), which reside in the perivascular space of the periodontium, possess characteristics of mesenchymal stem cells and are a promising tool for periodontal regeneration. Recently, great progress has been made in PDLSC transplantation. Investigators are attempting to maximize the proliferation and differentiation potential of PDLSCs by modifying culture conditions and applying growth factors. Nevertheless, problems remain. First, incomparability among different studies must be minimized by establishing standard guidelines for culture and identification of PDLSCs. Notably, attention should be paid to the biological safety of PDLSC transplantation. The present review updates the latest findings regarding PDLSCs and discusses standard criteria for culture and identification of PDLSCs. Finally, the review calls for careful consideration of PDLSC transplantation safety. |
| format | Article |
| id | doaj-art-a1d2dd65fb0a49fbbf24d183d473c761 |
| institution | OA Journals |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-a1d2dd65fb0a49fbbf24d183d473c7612025-08-20T02:20:42ZengWileyStem Cells International1687-966X1687-96782015-01-01201510.1155/2015/972313972313Periodontal Ligament Stem Cells: Current Status, Concerns, and Future ProspectsWenjun Zhu0Min Liang1Department of Periodontology, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, 56 Ling Yuan Road West, Guangzhou, Guangdong 510055, ChinaDepartment of Periodontology, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, 56 Ling Yuan Road West, Guangzhou, Guangdong 510055, ChinaPeriodontal ligament stem cells (PDLSCs), which reside in the perivascular space of the periodontium, possess characteristics of mesenchymal stem cells and are a promising tool for periodontal regeneration. Recently, great progress has been made in PDLSC transplantation. Investigators are attempting to maximize the proliferation and differentiation potential of PDLSCs by modifying culture conditions and applying growth factors. Nevertheless, problems remain. First, incomparability among different studies must be minimized by establishing standard guidelines for culture and identification of PDLSCs. Notably, attention should be paid to the biological safety of PDLSC transplantation. The present review updates the latest findings regarding PDLSCs and discusses standard criteria for culture and identification of PDLSCs. Finally, the review calls for careful consideration of PDLSC transplantation safety.http://dx.doi.org/10.1155/2015/972313 |
| spellingShingle | Wenjun Zhu Min Liang Periodontal Ligament Stem Cells: Current Status, Concerns, and Future Prospects Stem Cells International |
| title | Periodontal Ligament Stem Cells: Current Status, Concerns, and Future Prospects |
| title_full | Periodontal Ligament Stem Cells: Current Status, Concerns, and Future Prospects |
| title_fullStr | Periodontal Ligament Stem Cells: Current Status, Concerns, and Future Prospects |
| title_full_unstemmed | Periodontal Ligament Stem Cells: Current Status, Concerns, and Future Prospects |
| title_short | Periodontal Ligament Stem Cells: Current Status, Concerns, and Future Prospects |
| title_sort | periodontal ligament stem cells current status concerns and future prospects |
| url | http://dx.doi.org/10.1155/2015/972313 |
| work_keys_str_mv | AT wenjunzhu periodontalligamentstemcellscurrentstatusconcernsandfutureprospects AT minliang periodontalligamentstemcellscurrentstatusconcernsandfutureprospects |