A comparative observational study of fetomaternal outcome in gestational hypertension cases in coronavirus disease 2019 versus noncoronavirus disease 2019 patients
Background Coronavirus disease 2019 (COVID-19) which primarily involves the pulmonary system can also cause systemic involvement by panvascular endothelial dysfunction. Gestational hypertension is a systemic disease of maternal endothelial dysfunction which can progress to preeclampsia, eclampsia, a...
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Wolters Kluwer Medknow Publications
2024-10-01
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| Series: | MRIMS Journal of Health Sciences |
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| Online Access: | https://journals.lww.com/10.4103/mjhs.mjhs_10_23 |
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| author | Sangeeta Shah Rajala Usha Rani P. Divya Daniel C. H. Udaya Sri |
| author_facet | Sangeeta Shah Rajala Usha Rani P. Divya Daniel C. H. Udaya Sri |
| author_sort | Sangeeta Shah |
| collection | DOAJ |
| description | Background
Coronavirus disease 2019 (COVID-19) which primarily involves the pulmonary system can also cause systemic involvement by panvascular endothelial dysfunction. Gestational hypertension is a systemic disease of maternal endothelial dysfunction which can progress to preeclampsia, eclampsia, and multi-organ failure. Both the entities: COVID-19 and preeclampsia appeared to have camouflaged scenarios ultimately, presenting as endothelial dysfunction.
Objective
The present study aimed to estimate the number of COVID-19 and non-COVID-19 patients with gestational hypertension developing preeclampsia and their fetomaternal outcome in the third trimester.
Materials and Methods
It was a comparative observational study conducted in the Department of Obstetrics and Gynecology at Gandhi Hospital, Secunderabad, over a period of 18 months during the COVID-19 pandemic. One hundred women diagnosed with gestational hypertension were considered and their maternal and fetal complications were studied. They were divided into two groups based on the history of symptomatic COVID-19 infection and the COVID-19 reverse transcription–polymerase chain reaction (RT-PCR) report.
Results
The incidence of severe preeclampsia was more in the gestational hypertension with COVID-19 group (60%) when compared to the non-COVID-19 group (36%) (P = 0.016). The incidence of maternal deaths in the gestational hypertension with COVID-19 group was 20% (P = 0.08). Incidence of intrauterine growth restriction was 20% (P = 0.205) and neonatal deaths was 14% (P = 0.538) in the gestational hypertension with COVID-19 group.
Conclusion
Preeclampsia and COVID-19 infection during pregnancy were closely related with each other. In a synergistic fashion, COVID-19 infection with preeclampsia increases the risk of adverse maternal and perinatal outcomes. |
| format | Article |
| id | doaj-art-a1cf959e20fe4db1bd6b60aa13466a2b |
| institution | OA Journals |
| issn | 2321-7006 2321-7294 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | MRIMS Journal of Health Sciences |
| spelling | doaj-art-a1cf959e20fe4db1bd6b60aa13466a2b2025-08-20T02:12:47ZengWolters Kluwer Medknow PublicationsMRIMS Journal of Health Sciences2321-70062321-72942024-10-0112423523910.4103/mjhs.mjhs_10_23A comparative observational study of fetomaternal outcome in gestational hypertension cases in coronavirus disease 2019 versus noncoronavirus disease 2019 patientsSangeeta ShahRajala Usha RaniP. Divya DanielC. H. Udaya SriBackground Coronavirus disease 2019 (COVID-19) which primarily involves the pulmonary system can also cause systemic involvement by panvascular endothelial dysfunction. Gestational hypertension is a systemic disease of maternal endothelial dysfunction which can progress to preeclampsia, eclampsia, and multi-organ failure. Both the entities: COVID-19 and preeclampsia appeared to have camouflaged scenarios ultimately, presenting as endothelial dysfunction. Objective The present study aimed to estimate the number of COVID-19 and non-COVID-19 patients with gestational hypertension developing preeclampsia and their fetomaternal outcome in the third trimester. Materials and Methods It was a comparative observational study conducted in the Department of Obstetrics and Gynecology at Gandhi Hospital, Secunderabad, over a period of 18 months during the COVID-19 pandemic. One hundred women diagnosed with gestational hypertension were considered and their maternal and fetal complications were studied. They were divided into two groups based on the history of symptomatic COVID-19 infection and the COVID-19 reverse transcription–polymerase chain reaction (RT-PCR) report. Results The incidence of severe preeclampsia was more in the gestational hypertension with COVID-19 group (60%) when compared to the non-COVID-19 group (36%) (P = 0.016). The incidence of maternal deaths in the gestational hypertension with COVID-19 group was 20% (P = 0.08). Incidence of intrauterine growth restriction was 20% (P = 0.205) and neonatal deaths was 14% (P = 0.538) in the gestational hypertension with COVID-19 group. Conclusion Preeclampsia and COVID-19 infection during pregnancy were closely related with each other. In a synergistic fashion, COVID-19 infection with preeclampsia increases the risk of adverse maternal and perinatal outcomes.https://journals.lww.com/10.4103/mjhs.mjhs_10_23coronavirus disease 2019endothelial dysfunctiongestational hypertension |
| spellingShingle | Sangeeta Shah Rajala Usha Rani P. Divya Daniel C. H. Udaya Sri A comparative observational study of fetomaternal outcome in gestational hypertension cases in coronavirus disease 2019 versus noncoronavirus disease 2019 patients MRIMS Journal of Health Sciences coronavirus disease 2019 endothelial dysfunction gestational hypertension |
| title | A comparative observational study of fetomaternal outcome in gestational hypertension cases in coronavirus disease 2019 versus noncoronavirus disease 2019 patients |
| title_full | A comparative observational study of fetomaternal outcome in gestational hypertension cases in coronavirus disease 2019 versus noncoronavirus disease 2019 patients |
| title_fullStr | A comparative observational study of fetomaternal outcome in gestational hypertension cases in coronavirus disease 2019 versus noncoronavirus disease 2019 patients |
| title_full_unstemmed | A comparative observational study of fetomaternal outcome in gestational hypertension cases in coronavirus disease 2019 versus noncoronavirus disease 2019 patients |
| title_short | A comparative observational study of fetomaternal outcome in gestational hypertension cases in coronavirus disease 2019 versus noncoronavirus disease 2019 patients |
| title_sort | comparative observational study of fetomaternal outcome in gestational hypertension cases in coronavirus disease 2019 versus noncoronavirus disease 2019 patients |
| topic | coronavirus disease 2019 endothelial dysfunction gestational hypertension |
| url | https://journals.lww.com/10.4103/mjhs.mjhs_10_23 |
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