α-Alkylation of (S)-Glyceric Acid through the tert-Butylthioester of (2R,4S)-2-tert-Butyl-1,3-dioxolane-4-carboxylic Acid
The thioester (9) mentioned in the title is prepared in three steps from (S)-serine. Deprotonation with LiN(CHMe2)2 generates a chiral enolate (10) which is alkylated preferentially from the Re-face (cis to the tert-butyl group), to give products of type 11. Possible reasons for the steric course o...
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| Main Authors: | , |
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| Format: | Article |
| Language: | deu |
| Published: |
Swiss Chemical Society
1985-01-01
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| Series: | CHIMIA |
| Online Access: | https://www.chimia.ch/chimia/article/view/9642 |
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