Dysregulated RBM24 phosphorylation impairs APOE translation underlying psychological stress-induced cardiovascular disease

Dysregulated RBM24 phosphorylation impairs APOE translation underlying psychological stress-induced cardiovascular disease

Abstract Psychological stress contributes to cardiovascular disease (CVD) and sudden cardiac death, yet its molecular basis remains obscure. RNA binding protein RBM24 plays a critical role in cardiac development, rhythm regulation, and cellular stress. Here, we show that psychological stress activat...

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Main Authors: He Yang, Lei Sun, Xuemei Bai, Bingcheng Cai, Zepeng Tu, Chen Fang, Yusheng Bian, Xiaoyu Zhang, Xudong Han, Dayin Lv, Chi Zhang, Bo Li, Shaoxiang Luo, Bingbing Du, Lan Li, Yufeng Yao, Zhiqiang Dong, Zhuowei Huang, Guanhua Su, Hui Li, Qing K. Wang, Min Zhang
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54519-0
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