Complex regulation of the sirtuin-dependent reversible lysine acetylation system of Salmonella enterica
The extensive involvement of the reversible lysine acylation (RLA) system in metabolism has attracted the attention of investigators interested in understanding the fundamentals of prokaryotic and eukaryotic cell function. Research in this area of cell physiology is diverse,...
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| Language: | English |
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Shared Science Publishers OG
2015-10-01
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| Series: | Microbial Cell |
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| Online Access: | http://microbialcell.com/researcharticles/complex-regulation-of-the-sirtuin-dependent-reversible-lysine-acetylation-system-of-salmonella-enterica/ |
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| author | Kristy L. Hentchel Jorge C. Escalante-Semerena |
| author_facet | Kristy L. Hentchel Jorge C. Escalante-Semerena |
| author_sort | Kristy L. Hentchel |
| collection | DOAJ |
| description | The extensive involvement of the reversible lysine acylation (RLA) system in metabolism has attracted the attention of investigators interested in understanding the fundamentals of prokaryotic and eukaryotic cell function. Research in this area of cell physiology is diverse, ranging, among others, from probing the molecular bases of human diseases, to optimizing engineered metabolic pathways for biotechnological applications, to advancing our understanding of fundamental cellular processes. A gap of knowledge exists in our understanding of the regulatory circuitry that integrates the expression of genes encoding modifiers (i.e., acyltransferases) and demodifiers (i.e., deacylases) with the expression of genes encoding known targets of the system. Here we discuss the implications of recently reported work performed in the enteropathogen Salmonella enterica (mBio (2015) 6(4):e00891-15), which provided the first insights into the integration of the transcriptional regulation of genes encoding the RLA system with the acs gene encoding the central metabolic enzyme acetyl-CoA synthetase (Acs). |
| format | Article |
| id | doaj-art-a1c0dc49d8b240b1b42fdbb6c06b352f |
| institution | OA Journals |
| issn | 2311-2638 |
| language | English |
| publishDate | 2015-10-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Microbial Cell |
| spelling | doaj-art-a1c0dc49d8b240b1b42fdbb6c06b352f2025-08-20T02:04:33ZengShared Science Publishers OGMicrobial Cell2311-26382015-10-0121145145310.15698/mic2015.11.239123455678Complex regulation of the sirtuin-dependent reversible lysine acetylation system of Salmonella entericaKristy L. Hentchel0Jorge C. Escalante-Semerena1Department of Microbiology, University of Georgia, Athens, GA 30602, USA.Department of Microbiology, University of Georgia, Athens, GA 30602, USA.The extensive involvement of the reversible lysine acylation (RLA) system in metabolism has attracted the attention of investigators interested in understanding the fundamentals of prokaryotic and eukaryotic cell function. Research in this area of cell physiology is diverse, ranging, among others, from probing the molecular bases of human diseases, to optimizing engineered metabolic pathways for biotechnological applications, to advancing our understanding of fundamental cellular processes. A gap of knowledge exists in our understanding of the regulatory circuitry that integrates the expression of genes encoding modifiers (i.e., acyltransferases) and demodifiers (i.e., deacylases) with the expression of genes encoding known targets of the system. Here we discuss the implications of recently reported work performed in the enteropathogen Salmonella enterica (mBio (2015) 6(4):e00891-15), which provided the first insights into the integration of the transcriptional regulation of genes encoding the RLA system with the acs gene encoding the central metabolic enzyme acetyl-CoA synthetase (Acs).http://microbialcell.com/researcharticles/complex-regulation-of-the-sirtuin-dependent-reversible-lysine-acetylation-system-of-salmonella-enterica/sirtuin deacetylase (CobB)protein acetyltransferase (Pat)reversible lysine acetylation (RLA)transcriptional regulationIolRmyo-inositol utilizationSalmonella |
| spellingShingle | Kristy L. Hentchel Jorge C. Escalante-Semerena Complex regulation of the sirtuin-dependent reversible lysine acetylation system of Salmonella enterica Microbial Cell sirtuin deacetylase (CobB) protein acetyltransferase (Pat) reversible lysine acetylation (RLA) transcriptional regulation IolR myo-inositol utilization Salmonella |
| title | Complex regulation of the sirtuin-dependent reversible lysine acetylation system of Salmonella enterica |
| title_full | Complex regulation of the sirtuin-dependent reversible lysine acetylation system of Salmonella enterica |
| title_fullStr | Complex regulation of the sirtuin-dependent reversible lysine acetylation system of Salmonella enterica |
| title_full_unstemmed | Complex regulation of the sirtuin-dependent reversible lysine acetylation system of Salmonella enterica |
| title_short | Complex regulation of the sirtuin-dependent reversible lysine acetylation system of Salmonella enterica |
| title_sort | complex regulation of the sirtuin dependent reversible lysine acetylation system of salmonella enterica |
| topic | sirtuin deacetylase (CobB) protein acetyltransferase (Pat) reversible lysine acetylation (RLA) transcriptional regulation IolR myo-inositol utilization Salmonella |
| url | http://microbialcell.com/researcharticles/complex-regulation-of-the-sirtuin-dependent-reversible-lysine-acetylation-system-of-salmonella-enterica/ |
| work_keys_str_mv | AT kristylhentchel complexregulationofthesirtuindependentreversiblelysineacetylationsystemofsalmonellaenterica AT jorgecescalantesemerena complexregulationofthesirtuindependentreversiblelysineacetylationsystemofsalmonellaenterica |