CMV pneumonia following Temozolomide in Primary CNS Lymphoma.
Temozolomide (TMZ) is a second-generation alkylating agent introduced to therapy of primary brain tumors. Using TMZ there is an increased risk of infection. Literature reported several cases of PJ pneumonia but only 6 cases of CMV disease. This case presented the 1st patient with persistent CMV reac...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2014-08-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
| Online Access: | https://mjhid.org/index.php/mjhid/article/view/1891 |
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| Summary: | Temozolomide (TMZ) is a second-generation alkylating agent introduced to therapy of primary brain tumors. Using TMZ there is an increased risk of infection. Literature reported several cases of PJ pneumonia but only 6 cases of CMV disease. This case presented the 1st patient with persistent CMV reactivation and CMV disease previously not treated with Rituximab. A 44-year-old man was diagnosed with a occipital-PCNSL. As salvage treatment he was started with whole brain radiotherapy in association with TMZ. After some days CMV-DNA on blood resulted positive so a preemptive tp was commenced. After 2 weeks of Ganciclovir treatment it was replaced with Foscavir for persistent CMV-DNA positivity and the appearance of respiratory failure symptoms, highly suggested for CMV pneumonia.After 5 weeks of treatment,the patient improved and the CMV load became negative. |
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| ISSN: | 2035-3006 |